Scientists propose potential method for imaging-guided synergistic cancer therapy

Scientists propose potential method for imaging-guided synergistic cancer therapy
Graphic of CNQD-CN for NIR imaging and combined chemotherapy and phototherapy to treat cancer. Credit: Liu Hongji

A joint research team led by Prof. Wang Hui and Prof. Lin Wenchu from the High Magnetic Field Laboratory of the Hefei Institutes of Physical Science developed a synthesis of metal-free multifunctional therapeutic reagents, called graphitic carbon nitride quantum dots embedded in carbon nanosheets (CNQD-CN), via a one-step hydrothermal treatment.

Metal-free multifunctional nanomaterials have broad application prospects in integrated and treatment.

The team took an (formamide) as the and nitrogen source and then developed CNQD-CN.

CNQD-CN can be utilized as a near-infrared (NIR)/pH dual-responsive drug delivery system to improve the response to chemotherapy. It possesses both light-to-heat conversion and singlet oxygen generation capabilities under a single NIR excitation wavelength for combined photodynamic and photothermal therapy.

"The combination of graphitic carbon nitride quantum dots and two-dimensional carbon-based nanomaterials might be a potential candidate for realizing imaging-guided synergistic cancer therapy due to its excellent performance, including , efficient light-to-heat conversion capability, and near-infrared (NIR)-induced singlet oxygen generation," said Wang Hui, who designed the project.

However, synthesis of related nanocomposites, including multiple reaction precursors, complex synthesis processes, potential weak interaction, produced large amounts of waste, thus limiting their scalable production and reproducibility.

This study was a further step in realizing the advantages of imaging-guided synergistic cancer therapy.


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More information: Hongji Liu et al, Graphitic Carbon Nitride Quantum Dots Embedded in Carbon Nanosheets for Near-Infrared Imaging-Guided Combined Photo-Chemotherapy, ACS Nano (2020). DOI: 10.1021/acsnano.0c05143
Journal information: ACS Nano

Citation: Scientists propose potential method for imaging-guided synergistic cancer therapy (2020, October 15) retrieved 27 October 2020 from https://phys.org/news/2020-10-scientists-potential-method-imaging-guided-synergistic.html
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