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Scientists have identified a unique molecular binding mechanism that helps keep non-mammalian creatures in sub-zero temperatures from freezing. Antifreeze glycoproteins (AFGPs), produced by polar fishes, inhibit ice growth ...
Chaperones are a set of proteins that are specialised to assist proteins in the human body. They help proteins to fold to the right shape and protect them from adapting wrong shapes. The research group of Alireza Mashaghi, ...
In a first for machine-learning algorithms, a new piece of software developed at Caltech can predict behavior of bacteria by reading the content of a gene. The breakthrough could have significant implications for our understanding ...
Nearly a dozen scientists across Oak Ridge National Laboratory are teaming with medical researchers and leveraging ORNL's biggest science tools to solve a modern-day biology grand challenge: unlocking the secrets of disordered ...
A team of researchers from Lobachevsky University (Nizhny Novgorod, Russia) headed by Professor Alexei Fedorov, chair of the Organic Chemistry Department, is working to create a new generation of targeted anti-cancer drugs ...
Practically all biochemical processes involve enzymes that accelerate chemical reactions. A research team from the Technical University of Munich (TUM) has now for the first time deciphered the molecular mechanism of the ...
The highly acidic environment in the stomach is essential for digestion. Furthermore, it acts as an important barrier to invasive pathogens. However, excessive stomach acidification leads to ulcers. Although this is not a ...
A team of scientists headed by Rosalind Franklin University Professor David M. Mueller, PhD, has solved the structure of mitochondrial ATP synthase, an enzyme that makes ATP, adenosine triphosphate, the major energy source ...
Last year, researchers from the University of Pennsylvania revealed surprising insights into how cells respond to surface curvature. Specifically, they investigated how cells respond to cylindrical surfaces, which are common ...
New research shows how and where tungsten accumulates in bones of mice exposed to the element through drinking water. The findings, by a team of chemists and biologists at McGill University, could add to doubts over the once-universal ...
A Virginia Tech research team in collaboration with researchers from the University of Missouri-Columbia have discovered a mechanism responsible for antibiotic resistance in the bacteria that cause tuberculosis and leprosy.
Scientists have engineered an enzyme which can digest some of our most commonly polluting plastics, providing a potential solution to one of the world's biggest environmental problems.
UCLA researchers have produced the clearest 3-D images to date of the virus that causes cold sores, herpes simplex virus type 1, or HSV-1. The images enabled them to map the virus' structure and offered new insights into ...
During the past several years, many strains of bacteria have become resistant to existing antibiotics, and very few new drugs have been added to the antibiotic arsenal.
UCLA biochemists have achieved a first in biology: viewing at near-atomic detail the smallest protein ever seen by the technique whose development won its creators the 2017 Nobel Prize in chemistry. That technique, called ...
In 2013, the Nobel Prize in Physiology or Medicine was awarded to three scientists for their contributions to uncovering the mechanisms governing vesicle transport in cells. Their explanations provided both a conceptual and ...
The discovery of a novel class of enzyme in human biology by scientists at the University of Dundee has opened a new area of research that could benefit patients suffering from a range of neurological disorders.
A multi-institutional project to understand one of the major targets of human drug design has produced new insights into how structural communication works in a cell component called a G protein-coupled receptor (GPCRs), ...
Northwestern Engineering researchers have developed a new way to manipulate a virus shell that self-assembles from proteins and holds promise as a carrier for disease detection, drug delivery, and vaccinations.
Anti-inflammatory drugs such as dexamethasone can have harmful side effects on the skin, bones and metabolism. Structural biology research from Emory University School of Medicine has implications for the long-standing quest ...
Oil spills and their impact on the environment are a source of concern for scientists. These disasters occur on a regular basis, leading to messy decontamination challenges that require massive investments of time and resources. ...
Beta-lactam antibiotics, including penicillin, are one of the most widely used classes of antibiotics in the world. Though they've been in use since the 1940s, scientists still don't fully understand what happens when this ...
Researchers have identified key molecular mechanisms at work when people smell musks, a highly valued group of fixatives used in many perfumes and colognes. The discovery may have implications for a wide range of effects ...
Scientists studying plant biochemistry at the U.S. Department of Energy's Brookhaven National Laboratory have discovered new details about biomolecules that put the brakes on oil production. The findings suggest that disabling ...
Researchers at Harvard Medical School, the University of California, San Francisco, and the University of Georgia have described how the protein that allows strep and staph bacteria to stick to human cells is prepared and ...
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Researchers at Valencia's Universitat Politècnica (UPV), the Valencia-CSIC Biomedicine Institute (IBV) and the Bioengineering, Biomaterial and Nanomedicine CIBER (CIBER BBN) have developed a new system to induce the death ...
The herpesvirus is genetically and structurally one of the most complex viruses. It spreads within the host population efficiently, causing a range of diseases in humans, including congenital disorders and cancers.
A team of researchers led by Dr. Mike Sleutel from the VIB-VUB Center for Structural Biology in collaboration with scientists from the Institute for Complex Molecular Systems of the Eindhoven University of Technology, and ...
Cells with stem-cell characteristics appear to be especially important in the formation and metastasis of tumors. Scientists have now developed a universal fluorescent probe for these "cancer stem cells". As reported in the ...
Researchers at USC and Harvard have developed a new approach to repair cells deep inside the ear—a potential remedy that could restore hearing for millions of elderly people and others who suffer hearing loss.
Every human cell is encased in a five-nanometer-thick lipid membrane that protects it from the surrounding environment. Like a gatekeeper, the membrane determines which ions and molecules can pass through. In so doing, it ...
Prostate cancer is the second most common cancer in men and the fifth leading cause of death from cancer in men worldwide, according to 2012 numbers. While several viable treatment options for prostate cancer exist, many ...
Not only can synthetic molecules mimic the structures of their biological models, they can also take on their functions and may even successfully compete with them, as an artificial DNA sequence designed by Ludwig-Maximilians-Universitaet ...
Scientists at the University of Dundee have identified the effects of a mutation that gives rise to a form of intellectual disability.
Researchers from MIPT and several U.S. and Chinese universities have solved the structure of one of the most important nervous system proteins in complex with a number of drug molecules. The discovery opens up opportunities ...
Biochemists from McGill University are getting a good look at just how a specific enzyme that is part of the human immune system interacts with a certain group of bacteria that are described as gram-negative.
A team of researchers from Whitehead Institute and the Howard Hughes Medical Institute has revealed the structure of a key protein complex in humans that transmits signals about nutrient levels, enabling cells to align their ...
Researchers from UT Southwestern's Charles and Jane Pak Center for Mineral Metabolism and Clinical Research and Internal Medicine's Division of Nephrology recently published work in Nature that reveals the molecular structure ...
Ludwig-Maximilians-Universitaet (LMU) researchers in Munich, Germany, have characterized the physical mechanism that enables a widespread bacterial pathogen to adhere to the tissues of its human host.
Scientists at the National Institute on Drug Abuse (NIDA) Intramural Research Program (IRP) have uncovered evidence that shows a more complex and elaborate role for the body's hard-working G protein-coupled receptors (GPCRs) ...
Searching for new drugs is like fishing in the dark: the prospect of catching something is very uncertain, and it requires patience, skill and – of course – money. ETH researchers led by Dario Neri have developed a new ...
Proteins constantly move and change their conformation. Molecular dynamics typically answers the question of what the possible conformations of proteins are. Proteins, however, have a highly complicated and crowded structure, ...
Cells can avoid "data breaches" when letting signaling proteins into their nuclei thanks to a quirky biophysical mechanism involving a blur of spaghetti-like proteins, researchers from the Rockefeller University and the Albert ...
Genetics is a crapshoot. During sexual reproduction, genes from both the mother and the father mix and mingle to produce a genetic combination unique to each offspring. In most cases, the chromosomes line up properly and ...
Growing global food demand, climate change, and climate policies favoring bioenergy production are expected to increase pressures on water resources around the world. Many analysts predict that water shortages will constrain ...
University of Arizona biology researchers have made a discovery that helps resolve a conundrum that has puzzled scientists for more than a century.
A multinational team of astronomers involving the University of Adelaide has catalogued over 70 sources of very high energy gamma rays, including 16 previously undiscovered ones, in a survey of the Milky Way using gamma ray ...
Many of NASA's most iconic spacecraft towered over the engineers who built them: think Voyagers 1 and 2, Cassini or Galileo—all large machines that could measure up to a school bus.
A team at Whitehead Institute and MIT has harnessed single-cell technologies to analyze over 65,000 cells from the regenerative planarian flatworm, Schmidtea mediterranea, revealing the complete suite of actives genes (or ...
Plants have become an unlikely subject of political debate. Many projections suggest that burning fossil fuels and the resulting climate change will make it harder to grow enough food for everyone in the coming decades. But ...
China's croplands have experienced drastic changes in management practices related to fertilization, tillage and residue treatment since the 1980s. The impact of these changes on soil organic carbon (SOC) has drawn major ...
An Archaeologist at The Australian National University (ANU) has discovered a prehistoric Bronze-Age barrow, or burial mound, on a hill in Cornwall and is about to start excavating the untouched site which overlooks the English ...
Researchers playing with a cloud of ultracold atoms uncovered behavior that bears a striking resemblance to the universe in microcosm. Their work, which forges new connections between atomic physics and the sudden expansion ...
Evidence that humans can genetically adapt to diving has been identified for the first time in a new study. The evidence suggests that the Bajau, a people group indigenous to parts of Indonesia, have genetically enlarged ...
Two and a half years ago, a team of researchers led by groups at MIT, the University of California at Berkeley, and Boston University announced a milestone: the fabrication of a working microprocessor, built using only existing ...
Our window into the cellular world just got a whole lot clearer.
Astronomers using ESA's XMM-Newton space observatory have probed the gas-filled haloes around galaxies in a quest to find 'missing' matter thought to reside there, but have come up empty-handed – so where is it?
Physicists at the University of Warwick have today, Thursday 19th April 2018, published new research in the fournal Science today 19th April 2018 (via the Journal's First Release pages) that could literally squeeze more power ...
An experiment that, by design, was not supposed to turn up anything of note instead produced a "bewildering" surprise, according to the Stanford scientists who made the discovery: a new way of creating gold nanoparticles ...
Diamond is well-known as the strongest of all natural materials, and with that strength comes another tightly linked property: brittleness. But now, an international team of researchers from MIT, Hong Kong, Singapore, and ...
To understand how a cell works, biologists like to take it apart. By removing genes from cells in diverse combinations, researchers have now uncovered how different genes work together to keep cells alive. The research will ...
Homo sapiens, Neanderthals and other recent human relatives may have begun hunting large mammal species down to size - by way of extinction - at least 90,000 years earlier than previously thought, says a new study published ...
Researchers from the University of Melbourne analysed the numbers of men and women authors listed on more than 10 million academic papers, allowing them to calculate the gender gap among researchers, as well as its rate of ...
It's not often that you see 50-year-old equipment in a modern physics laboratory, let alone find it at the center of cutting-edge research. But then, most such labs aren't run by Ronald Walsworth.
As Curiosity rover marches across Mars, the red planet's watery past comes into clearer focus.
All electronic devices consist of billions of transistors, the key building block invented in Bell Labs in the late 1940s. Early transistors were as large as one centimeter, but now measure about 14 nanometers. There has ...
Using genetic samples and computer simulations, evolutionary biologists have made a glass-half-full forecast: Corals in the Great Barrier Reef have enough genetic variation to adapt to and survive rising ocean temperatures ...
Neurons that remain active even after the triggering stimulus has been silenced form the basis of short-term memory. The brain uses rhythmically active neurons to combine larger groups of neurons into functional units. Until ...
Amongst the countless fascinating plants and animals inhabiting the tropical rainforests of Southeast Asia, there are the spectacular "exploding ants", a group of arboreal, canopy dwelling ants nicknamed for their unique ...
A hole in the skull of a Stone Age cow was likely made by humans about 5,000 years ago, probably by a primitive veterinarian or trainee surgeon, scientists said Thursday.
From one stem cell to many differentiated body cells: Scientists from the MDC in Berlin, along with collaborating researchers in Munich, have published a comprehensive lineage tree of a whole adult animal in the journal Science. ...
Researchers have developed a new way to improve our knowledge of the Big Bang by measuring radiation from its afterglow, called the cosmic microwave background radiation. The new results predict the maximum bandwidth of the ...
Using a homemade, high-tech microscope, scientists at the University of Virginia School of Medicine have revealed how a cancer-causing virus anchors itself to our DNA. That discovery could pave the way for doctors to cure ...
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