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A drug-like molecule developed by Duke Health researchers appears to intercede in an inflammatory response that is at the center of a variety of diseases, including some cancers, rheumatoid arthritis and Crohn's disease.
A new test to show the properties of biologically important enzymes could help to streamline development of new treatments.
Using a novel molecular analysis technique, scientists at The Scripps Research Institute (TSRI) have identified the chemical underpinnings of Captagon, also known as fenethylline, an illegal amphetamine-type stimulant that ...
A little-studied gene may explain how some liver cancer cells obtain the nutrition they need to proliferate, according to new research from the University of Maryland. The results of this research will be published as an ...
As antibiotic resistance rises and fears over superbugs grow, scientists are looking for new treatment options. One area of focus is antimicrobial peptides (AMPs), which could someday be an alternative to currently prescribed ...
Scientists from Trinity College Dublin have gained key structural insights into the machinery employed by opportunistic, disease-causing bacteria, which may help chemists design new drugs to inhibit them.
By understanding the functional differences between proteins expressed by two E. coli strains, researchers at Kansas State University are exploring new opportunities to inhibit their impacts to human health.
A multidisciplinary team of mathematicians, theoretical physicists, chemists and biochemists from the University of Bristol came together to study the self-assembly of protein building into protein cages with possible applications ...
Scientists have created a new way of screening compounds that is more sensitive than existing methods, opening up the possibility of finding new drugs for many diseases.
Tuberculosis has now surpassed HIV worldwide as the leading cause of death due to infectious disease. The bacteria that causes this disease, Mycobacterium tuberculosis (Mtb), is quickly developing resistance to currently ...
University of Georgia researchers have discovered a new way that iron is stored in microorganisms, a finding that provides new insights into the fundamental nature of how biological systems work. The research was recently ...
A new technique for evaluating drug safety can detect stress on cells at earlier stages than conventional methods, which mostly rely on detecting cell death. The new method uses a fluorescent sensor that is turned on in a ...
An ice cold drink is refreshing in the summer, but for people with sensitive teeth, it can cause a painful jolt in the mouth. This condition can be treated, but many current approaches don't last long. Now researchers report ...
Adding onions to a recipe can make a meal taste rich and savory, but cutting up the onion can be brutal. Onions release a compound called lachrymatory factor (LF), which makes the eyes sting and water. Scientists know that ...
A method for designing antibiotics based on random binary encoding, developed by a team led by the National Physical Laboratory (NPL), could open up new opportunities in drug discovery.
One of the most potent toxins known acts by welding the two strands of the famous double helix together in a unique fashion which foils the standard repair mechanisms cells use to protect their DNA.
Each cell in the body is made up of a number of tiny sealed membranous subunits called organelles, and they send things like lipids back and forth to allow the cell to function. A process called membrane tethering is responsible ...
Two new discoveries from Edward Yu's Iowa State University laboratory are adding to the scientific understanding of how bacteria resist antibiotics.
Computer models developed by Brown University mathematicians show new details of what happens inside a red blood cell affected by sickle cell disease. The researchers said they hope their models, described in an article in ...
The structure of a protein key to the survival and spread of a virus that affects salmon could inform strategies to treat the flu in humans, according to scientists at Rice University.
New research suggests that a man-made cousin of a small molecule found in olive oil can disrupt the hunger-signaling pathway. Researchers identified this promising new target by screening a library of roughly 1,600 small ...
A team spearheaded by Van Andel Research Institute scientists has answered a long-standing question that may lead to more effective drugs with fewer side effects for diseases ranging from heart failure to cancer.
It's well known that calcium is essential for strong bones and teeth, but new research shows it also plays a key role in moderating another important aspect of health—cholesterol.
The structure of the critical quality control checkpoint enzyme that oversees the production of thousands of secreted glycoproteins has been solved by a fruitful collaborative effort at Diamond Light Source. The study, recently ...
Lipids play a key role in many metabolic diseases, including hypertension, diabetes, and stroke. So having a complete profile of the body's lipids—its "lipidome"—is important.
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Around half of all medications for chronic diseases are not taken as prescribed, costing the U.S. health care system more than $100 billion in avoidable hospital stays each year.
One of the hardest parts in drug discovery is pinning down how a medicine actually works in the body. It took nearly 100 years to uncover the molecular target of aspirin, but even with cutting-edge technology, it can take ...
Copper has long been known for its ability to kill bacteria and other microbes.
ETH microbiologists led by Markus Künzler have discovered a remarkable enzyme in a fungus. They now want to use it to develop new drugs.
Proteins are the building blocks of life and biological agents. They are drivers of growth and development and the spread of viruses and bacteria, and have key roles in disease pathways and virtually all cellular functions. ...
Ion channels in the membrane vesicles that mediate intracellular protein transport play a crucial role in cell physiology. A method developed by an Ludwig-Maximilians-Universitaet (LMU) in Munich team now allows them to be ...
Researchers at Purdue University have uncovered the way some antibodies neutralize infections caused by viruses.
Time is of the essence when treating a patient undergoing a heart attack. Cardiac surgeons attempt to quickly stabilize the heart by applying reperfusion, a technique that restores oxygen to the heart by opening up blocked ...
Scientists at the Technische Universität Darmstadt, Ludwig Maximilians University (LMU) Munich and the Leibniz Institute for Molecular Pharmacology (FMP) have managed to introduce tiny antibodies into living cells. The researchers ...
Enzyme activity is determined by the structure of a particular region of a protein called the active site. The generation of completely new active sites capable of enzyme catalysis is, arguably, one of the most fundamental ...
Bacteria or 'superbugs' that have adapted to resist multiple antibiotics are responsible for around 700,000 deaths globally a year; new types of antibiotics are urgently needed.
Photosynthesis, which allows energy from the sun to be converted into life-sustaining sugars, can also be hazardous to green plants. If they absorb too much sunlight, the extra energy destroys their tissue.
EPFL scientists have developed a ligand molecule that connects peptide drugs to blood-serum albumin and keeps them from being cleared out by the kidneys too soon. The ligand is easy to synthesize and can extend the half-life ...
A simple methodology for capturing proteins implicated in the development of Alzheimer's disease and other conditions has been developed by researchers at the University of Bradford and University of Dundee.
Researchers at the University of California, Riverside have converted a naturally occurring fluorescent protein from corals into a biosensor that can be used to monitor the cellular thioredoxin (Trx) system, which is a promising ...
The stage is set for a new era of data-driven protein molecular engineering as advances in DNA synthesis technology merge with improvements in computational design of new proteins.
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase. Now the group is introducing the first three-dimensional structural ...
A*STAR researchers have created synthetic molecules to treat fungal keratitis – an infection of the cornea that causes visual disability. The new molecules are a first step toward developing effective drugs to combat this ...
Microbes dominate the planet, especially the ocean, and help support the entire marine food web. In a recent report published in Nature Microbiology, University of Hawai'i at Mānoa (UHM) oceanography professor Ed DeLong ...
In what could be a small step for science potentially leading to a breakthrough, an engineer at Washington University in St. Louis has taken steps toward using nanocrystal networks for artificial intelligence applications.
By combining an FDA-approved cancer immunotherapy with an emerging tumor-roasting nanotechnology, Duke University researchers improved the efficacy of both therapies in a proof-of-concept study using mice.
A new study from Indiana University-Purdue University Indianapolis validates that the central core of the East Antarctic ice sheet should remain stable even if the West Antarctic ice sheet melts.
When Israeli scientist Daniel Shechtman first saw a quasicrystal through his microscope in 1982, he reportedly thought to himself, "Eyn chaya kazo"—Hebrew for, "There can be no such creature."
Researchers have discovered a new reaction mechanism that could be used to improve catalyst designs for pollution control systems to further reduce emissions of smog-causing nitrogen oxides in diesel exhaust.
Ignore the snobs, because most experts agree: a few drops of water enhance the taste of whiskies, from well-rounded blends to peat bombs redolent of smoke, tobacco and leather.
The roundworm stars in the first-ever compilation of gene readouts in every kind of cell in an animal. The readouts, which were taken at a particular stage in the worm's life, reveal, for example, which genes are turned on ...
It all began with a bet at a conference in Italy in 2013. Nicolas Vogel, Ph.D., then a postdoctoral fellow in Joanna Aizenberg's lab at the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard's ...
Astrophysicists at the University of Texas at Arlington have predicted that an Earth-like planet may be lurking in a star system just 16 light years away.
The earliest introduction of domestic chickens and black rats from Asia to the east coast of Africa came via maritime routes between the 7th and 8th centuries AD. In a paper published August 17, 2017 in the journal PLOS ONE, ...
Life as a fruit fly seems pretty simple: Hatch, grow, eat some fruit, find a mate, produce hundreds of tiny offspring and die—all in a month or so.
Farmers can grow big, juicy tomatoes thanks to a mutation in the Cell Size Regulator gene that occurred during the tomato domestication process. Esther van der Knaap of the University of Georgia, Athens and colleagues describe ...
Bacteria have to watch out for amoeba. Hungry amoebae hunt them: they catch them with their pseudopodia and then absorb and digest them.
Over the last decade, scientists have discovered tiny pieces of plastic in many ocean waters, and even in deep-sea mud. However, they know very little about how microplastics are transported within the ocean. A new paper ...
Spacewalking cosmonauts set free the world's first satellite made almost entirely with a 3-D printer on Thursday.
(Phys.org)—A trio of researchers with Universidad Católica del Norte and the Max-Planck-Institut für Radioastronomie has found evidence that suggests that convection alone cannot account for the amount of material that ...
Queen ants spend most of their time having babies. To reign supreme in a colony, they exude a special scent, or pheromone, on the waxy surface of their body that suppresses ovary development in their sisters, rendering the ...
Researchers recently showed that migratory reed warblers depend on an internal geomagnetic map to guide them on their long-distance journeys. But it wasn't clear how the birds were solving the relatively difficult "longitude ...
Researchers at the University of Illinois have discovered a mechanism that allows bacteria of the same species to communicate when their survival is threatened. The study suggests it may be possible to slow dangerous infections ...
Cartilage in our joints contains collagen which behaves a bit like the liquid crystals on a smart phone screen, according to researchers at Queen Mary University of London (QMUL).
Researchers have developed a new terahertz imaging approach that, for the first time, can acquire micron-scale resolution images while retaining computational approaches designed to speed up image acquisition. This combination ...
X-rays make the invisible visible: they permit the way materials are structured to be determined all the way down to the level of individual atoms. In the 1950s it was x-rays which revealed the double-helix structure of DNA. ...
A breakthrough 'recipe' for inkjet printing, which could enable high-volume manufacturing of next-generation laser and optoelectronic technologies, has been uncovered by Cambridge researchers.
The C. elegans roundworm sees by eating, sucking in big gulps of bacteria to learn about its surrounding environment. As researchers watched, they noticed an odd pattern marked by "bursts" of eating.
Researchers say their new knowledge on the inner workings of a bacterium has important implications for Australia's billion dollar cheese industry.
Imagine being able to see the signs of cancer decades before we can now. URI Chemical Engineering Assistant Professor Daniel Roxbury and researchers from Memorial Sloan Kettering Cancer Center have invented a technique that ...
Mexican scientists said Wednesday they have discovered the fossilized remains of a previously unknown species of giant sloth that lived 10,000 years ago and died at the bottom of a sinkhole.
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new ...
More than 50 years ago, at the dawn of human spaceflight, the first brave astronauts were only able to communicate with mission control operators on Earth for about 15 percent of each orbit. If this were true today, the International ...
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