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For more than a decade, scientists have worked to understand the connection between colibactin, a compound produced by certain strains of E. coli, and colorectal cancer, but have been hampered by their inability to isolate ...
Cholesterol carried in high-density lipoprotein particles, or HDL cholesterol, has been dubbed the good cholesterol, because people whose HDL levels are high have a lower risk of developing heart disease. That link was first ...
Using a novel optogenetic tool, researchers have successfully controlled, reproduced and visualised serotonin receptor signals in neural cells. To this end, they modified a photosensitive membrane receptor in the eye, namely ...
A new method uses fluorescence to detect potentially disease-causing forms of proteins as they unravel due to stress or mutations. A team of researchers from Penn State and the University of Washington reengineered a fluorescent ...
A team of physicists from Immanuel Kant Baltic State University have suggested a method to identify single antibiotic-resistant tuberculosis-causing bacteria. The new method detects the bacteria and evaluates their resistance ...
An international scientific group including a RUDN chemist have developed a complex copper-based compound with stronger antibacterial properties compared to analogs, and is cheaper to produce. The scientists confirmed that ...
Old molecules and new complexes: researchers at Hollings Cancer Center at the Medical University of South Carolina (MUSC) have discovered cell membrane complexes called ceramidosomes that may be a new target for drugs to ...
Although moderately mobile, marine cone snails have perfected several strategies to capture prey. Some fish-hunting species release venom into the surrounding water. Within the plume of toxic venom, the fish succumbs to fast-acting ...
Cornell University scientists Rachel Hestrin and Johannes Lehmann, along with collaborators from Canada and Australia, have shown that charcoal can mop up large quantities of nitrogen from the air pollutant ammonia, resulting ...
RUDN medics report that exposure to organotin compounds may cause metabolic disturbance and therefore lead to obesity. Being aware of the mechanisms of such exposure, doctors can neutralize the effect of the toxins. The work ...
RUDN biochemists found a way to reduce the activity of telomerase (the enzyme of cell immortality) 10-fold. The discovery could lead to new antitumor drugs and give a better understanding of how the activity of the enzyme ...
The detection of physical forces is one of the most complex challenges facing science. Although Newton solved the problem of gravity long ago, imaging the physical forces that act within living cells remains one of the main ...
Researchers have designed a machine learning algorithm for drug discovery which has been shown to be twice as efficient as the industry standard, which could accelerate the process of developing new treatments for disease.
Proteins fold according to a script written in the pattern of their amino acids. But to function properly, some parts must ad-lib.
Early in the course of Alzheimer's disease—long before future patients begin to notice symptoms—neurofibrillary tangles composed of tau protein aggregates begin to form in their brain cells. How toxic these aggregates ...
Experiments at DESY's X-ray source PETRA III have revealed the first structure of a biological transporter protein loaded with a pro-drug. Prodrugs are inactive medications that are metabolized into an active, functional ...
NUS biophysicists have discovered new conformational changes and structural dynamics of the dengue virus during their transmission to human hosts.
The fungus Aspergillus fumigatus is everywhere, and is extremely dangerous for people with weakened immune systems. It occurs virtually everywhere on Earth, as a dark grey stain on damp walls or in microscopically small spores ...
Physicists from the University of Basel have developed a new method to examine the elasticity and binding properties of DNA molecules on a surface at extremely low temperatures. With a combination of cryo-force spectroscopy ...
A Rutgers-led team has discovered two genes that make some strains of harmful Staphyloccocus bacteria resistant to treatment by copper, a potent and frequently used antibacterial agent.
People are great at detecting cold temperatures and also the cool sensation induced by natural substances like menthol, which is common in remedies used to soothe aching muscles. But it hasn't been entirely clear how we do ...
To unravel the mysterious mechanisms of drug potency for the treatment of cardiac arrhythmias, a group of researchers at UC Davis have developed novel simulations that provide insights on vital atomic-scale drug-cardiac cells ...
For decades, scientists and doctors have known that bacteria in soil were capable of manufacturing streptozotocin, an antibiotic compound that is also an important treatment for certain types of pancreatic cancer.
Researchers have launched an ultra-large virtual docking library expected to grow to more than 1 billion molecules by next year. It will expand by 1000-fold the number of such "make-on-demand" compounds readily available ...
The ScenoProt project has analysed the nutrient composition and the most typical bioactive compounds of high-protein plants. Analyses aimed to identify the amount of proteins, the amino acid composition, fibres and the concentrations ...
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Phosphate is a key element in many processes in the body and essential for global food production. Researchers at the University of Göttingen have now developed a method to detect new enzymes from the environment that can ...
Much like shoelaces or dangly necklaces, DNA strands can tangle up in unruly knots. Specialized enzymes keep DNA organized when cells divide, so the cells split smoothly and don't get stuck. But in tumor cells, this failsafe ...
A new compound based on Iridium, a rare metal which landed in the Gulf of Mexico 66 M years ago, hooked onto albumin, a protein in blood, can attack the nucleus of cancerous cells when switched on by light, University of ...
Some types of cancer cannot be treated with classical chemotherapy. Scientists from Inserm, CNRS, Sorbonne University, PSL university, University Grenoble Alpes and ESRF, the European Synchrotron, are working on a metallorganic ...
The impressively high conversion rates of natural enzymes partly result from increasing the catalytic activity of a selected few amino acid side chains through precise positioning within the protein binding cavity. Scientists ...
Researchers at the University of Tübingen have discovered a natural substance that could compete with the controversial herbicide glyphosate: a newly discovered sugar molecule synthesized from cyanobacteria that inhibits ...
Rapeseed doesn't just contain oil but high-quality protein, too. However, protein extracts from rapeseed have an intense, bitter off-taste. A team led by food chemist Thomas Hofmann has now identified the substance that is ...
Studies of human monoclonal antibodies isolated from survivors of coronavirus-induced severe acute respiratory syndrome (SARS) or Middle-East respiratory syndrome (MERS) are unveiling surprising immune defense tactics against ...
Membraneless assemblies of positively- and negatively-charged molecules can bring together RNA molecules in dense liquid droplets, allowing the RNAs to participate in fundamental chemical reactions. These assemblies, called ...
Which criteria do a synthetically created cell have to meet to be considered alive? What are the minimal requirements for individual functions of such a cell?
Exosomes regulate intercellular communication in cancers, and are drawing attention as a potential cancer biomarker. A Japanese research group has developed a highly sensitive method for detecting these exosomes that could ...
A team of researchers led by RCSI (Royal College of Surgeons in Ireland), have developed a new treatment for the particularly difficult-to-treat bone infection, osteomyelitis.
Bacterial cellulose (BC) is a cellulose material produced by microbial fermentation with a unique porous network structure. Functionalized BC has application prospects in many fields, such as chemical sensing, biological ...
Biological systems are truly representative of a complex macroscopic phenomenon, being acutely controlled by microscopic chemical reaction networks. As scientists seek to create a lifelike adaptive and responsive material, ...
Large molecules from dietary fiber, called polymers, can physically influence the environment in the small intestine by causing solid particles to group together (or aggregate), according to research published in eLife.
In the February 2019 issue of SLAS Discovery, a review by researchers from the University of Calabria (Italy) explores OCTNs, a small but intriguing group of transporters that are opening new frontiers in drug design research ...
A team of researchers have solved a 20-year riddle of how a crucial step in the biosynthesis of 'last-resort' antibiotics occurs.
Forces exerted by a living cell or a microorganism are tiny, often no larger than a few nanonewtons. For comparison, one nanonewton is the weight of one part in a billion of a typical chocolate bar. Yet, for biological cells ...
A new study published online in Meteoritics and Planetary Science finds that our most common meteorites, those known as L chondrites, come from at least two different debris fields in the asteroid belt. The belt contains ...
Even Georgia O'Keeffe noticed the pin-sized blisters bubbling on the surface of her paintings. For decades, conservationists and scholars assumed these tiny protrusions were grains of sand, kicked up from the New Mexico desert ...
A San Diego State University astrophysicist has helped discover evidence of a gigantic remnant surrounding an exploding star—a shell of material so huge, it must have been erupting on a regular basis for millions of years.
Peruvian archaeologists discovered an Incan tomb in the north of the country where an elite member of the pre-Columbian empire was buried, one of the investigators announced Friday.
NASA is accelerating plans to return Americans to the Moon, and this time, the US space agency says it will be there to stay.
Astronomers have spent decades looking for something that sounds like it would be hard to miss: about a third of the "normal" matter in the Universe. New results from NASA's Chandra X-ray Observatory may have helped them ...
Impacts from climate change are not always easy to see. But for many local businesses in coastal communities across the United States, the evidence is right outside their doors—or in their parking lots.
In a major analysis of university faculty and students in science, technology, engineering and math, Indiana University social psychologists found that professors' beliefs about intelligence play a measurable role in the ...
Cooperating with other people makes many things easier. However, competition is also a characteristic aspect of our society. In their struggle for contracts and positions, people have to be more successful than their competitors ...
Astronomy & Astrophysics publishes the work of researchers from the University of Vienna, who have found a river of stars, a stellar stream in astronomical parlance, covering most of the southern sky. The stream is relatively ...
New research has revealed the fascinating adaptation of some Australian sea snakes that helps protect their vulnerable paddle-shaped tails from predators.
Researchers at Duke University have discovered that a perfect absorber of electromagnetic waves they described in a 2017 paper can easily be tweaked into a sort of "time-reversed laser" known as a coherent perfect absorber ...
An international study led by researchers from the Institute of Space Sciences, from the Spanish National Research Council (CSIC) and the Institut d'Estudis Espacials de Catalunya has discovered that carbonaceous chondrites, ...
A team of researchers affiliated with several institutions in Austria and Germany has shown that introducing environmental noise to a line of ions can lead to enhanced transport of energy across them. In their paper published ...
Three years ago, when Richard Robinson, associate professor of materials science and engineering, was on sabbatical at Hebrew University in Israel, he asked a graduate student to send him some nanoparticles of a specific ...
The key to breeding disease-resistant honeybees could lie in a group of genes—known for controlling hygienic behaviour—that enable colonies to limit the spread of harmful mites and bacteria, according to genomics research ...
Just under three months after the final proton–proton collisions from the Large Hadron Collider (LHC)'s second run (Run 2), the CMS collaboration has submitted its first paper based on the full LHC dataset collected in ...
On February 1, 2019 a bright meteor crossed the sky over Cuba in the middle of the day. The phenomenon, which was followed by a smoke trail (a characteristic cloud left by the burn in the atmosphere of a meteoroid) and a ...
Hourly water level records collected from tide gauges can be used to measure land uplift caused by episodic tremor and slip of slow earthquakes in the Cascadia Subduction Zone, according to a new report in the Bulletin of ...
The iconic evergreen forests of the Pacific Northwest haven't always been here.
Scientists at the U.S. Department of Energy's Ames Laboratory have discovered a means of controlling the surface conductivity of a three-dimensional (3-D) topological insulator, a type of material that has potential applications ...
A study by University of Adelaide researchers and Queensland Government scientists has revealed what south-east Queensland's rainfall was like over the last 7000 years – including several severe droughts worse and longer ...
Coccolithophores are microscopic marine algae that use carbon dioxide to grow, and release carbon dioxide when they create their miniature calcite shells. These tiny, abundant planktonic microorganisms could therefore be ...
Many proteins with important biological functions are embedded in a biomembrane in the cells of humans and other living organisms. But how do they get in there in the first place? Researchers in the Department of Biosystems ...
Switching magnetic domains in magnetic memory normally requires magnetic fields generated by electrical currents, hence requiring large amounts of electrical power. Now, teams from France, Spain and Germany have demonstrated ...
Researchers have uncovered new evidence about the agriculturally important process of vernalization in a development that could help farmers deal with financially damaging weather fluctuations.
Researchers at the Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) have used one of the most advanced microscopes in the world to reveal the structure of a large protein complex crucial to photosynthesis, ...
What is a black hole? In an article that has just appeared in the journal Nature Astronomy, LMU philosopher Erik Curiel shows that physicists use different definitions of the concept, depending on their own particular fields ...
Queen Mary University of London has led a study which describes the first direct measurement of how energy is transferred from the chaotic electromagnetic fields in space to the particles that make up the solar wind, leading ...
Most schoolchildren learn that the Earth has three (or four) layers: a crust, mantle and core, which is sometimes subdivided into an inner and outer core. That's not wrong, but it does leave out several other layers that ...
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