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A team of researchers at Baylor College of Medicine and Texas Children's Hospital has revealed a connection between mTORC1 and Src, two proteins known to be hyperactive in cancer. The study, published in the journal Nature ...
Scientists at the UNC School of Medicine in collaboration with researchers at Oregon Health & Science University have resolved the three-dimensional molecular structure of the protein that's defective in people with cystic ...
Some bacterial pathogens, including those that cause strep throat and pneumonia, are able to create the components necessary to replicate their DNA without the usually required metal ions. This process may allow infectious ...
Pioneering research has given a fascinating fresh insight into how animal nervous systems evolved from simple structures to become the complex network transmitting signals between different parts of the body.
A measurable criterion now exists for determining the age rating of films. A group of scientists at the Max Planck Institute for Chemistry in Mainz has found that the concentration of isoprene in cinema air correlates with ...
How our bodies handle glucose—the simple sugar that provides energy from the food we eat—appears to be intertwined with how cells keep themselves functioning normally, according to new University of Chicago research.
Small heat-shock proteins (sHSPs) are molecular chaperones that bind to unfolded proteins to prevent protein aggregation and defend against cellular stress. Mutations in human sHSPs are associated with inherited diseases ...
Delivering functional genes into cells to replace mutated genes, an approach known as gene therapy, holds potential for treating many types of diseases. The earliest efforts to deliver genes to diseased cells focused on DNA, ...
Tübingen biochemists have discovered a natural mechanism of the body that can reduce the formation of dangerous blood clots, also known as thrombosis. So far, this antiblocking system has mainly been studied in mouse arteries. ...
The surfaces people interact with every day may seem rather mundane, but at the molecular scale, there is more activity than meets the eye.
When you get sick, you want the right treatment fast. But certain infectious microbes are experts at evading the very anti-bacterial drugs designed to fight them.
Designing synthetic proteins that can act as drugs for cancer or other diseases can be a tedious process: It generally involves creating a library of millions of proteins, then screening the library to find proteins that ...
Amino acids are the building blocks of proteins, and modifying amino acids chemically allows scientists to develop new molecules that can provide the starting point for developing new medical treatments such as antibiotics.
Yale researchers have developed a way to target RNA with small-molecule drugs, creating a new method for tapping into a vast number of biological mechanisms critical to metabolism and gene expression.
RNA has long been the neglected middle child of biomolecules, the go-between between DNA, which encodes the cell's instructions, and proteins, which carry them out. Increasingly, though, researchers are recognizing RNA as ...
A research group at Tohoku University has made a significant discovery with positive implications for the development of bacteria-fighting drugs. The aminoacyl-tRNA site (A-site) of the 16S RNA decoding region in the bacterial ...
University of Michigan researchers have developed a powerful microscope that can map how light energy migrates in photosynthetic bacteria on timescales of one-quadrillionth of a second.
The Tn antigen appears in 90 percent of cancers and is associated with metastasis. Thus, it is a promising biomarker for identifying cancer cells and has become a very attractive target in therapies to fight cancer, according ...
A 2016 study showed that exposure to urban pollution involving magnetite particles played a role in the development of Alzheimer's disease. It began from the hypothesis that magnetite particles would generate chemical reactions ...
Researchers have revealed the structure of an essential immune protein, creating future possibilities to develop more effective medicines for a range of illnesses from cancer to neurological diseases. University of Tokyo ...
Kidney stones—solid, pebble-like grit that forms when too much of certain minerals like calcium are in the urine—can strike men, women, and increasingly, children, and the presence and pain of stones afflicts more than ...
Researchers in the Department of Physiology & Biophysics at the University of California, Irvine School of Medicine have discovered the molecular basis for a therapeutic action of an ancient herbal medicine used across Africa ...
For the development of new medicinal agents, accurate knowledge of biological processes in the body is a prerequisite. Here proteins play a crucial role. At the Paul Scherrer Institute PSI, the X-ray free-electron laser SwissFEL ...
Malaria remains an economic and health burden to the developing world. As plasmodium, the causative agent of malaria, is acquiring rapid resistance against currently used drugs, identification of new classes of anti-malarials ...
In a recent study in the Journal of The American Chemical Society, Professor Tewodros Asefa and Associate Professor Jeffrey Boyd synthesized nanostructured silica particles, considered to be promising drug carriers, that ...
How life arose from non-living chemicals more than 3.5 billion years ago on Earth is a still-unanswered question. The RNA world hypothesis assumes that RNA biomolecules were key players during this time as they carry genetic ...
A team of researchers from the U.K. and the U.S. has found that a drug used to study hypoxia can also be used to inhibit glutamine metabolism—a possible means for targeting cancer cells by cutting off their supply line. ...
How the light-sensitive part of the biomolecule phytochrome changes from a light-adapted state to a dark-adapted state has been investigated by researchers at Ruhr-Universität Bochum and Philipps-Universität Marburg. So ...
Researchers at Utrecht University have gained new insights into the structure and function of a protein complex that maintains the outer membrane of a bacteria. Shutting down this protein complex makes it impossible for the ...
An old antibiotic, called nifuroxazide, could selectively kill dangerous cells within melanomas, the deadliest type of skin cancer, scientists from the Medical Research Council (MRC) Institute of Genetics and Molecular Medicine ...
A chemical compound found in common herbicides could help fight hospital-acquired human fungal pathogenic infections, which claim an estimated two million lives per year.
Researchers from Eindhoven University of Technology (The Netherlands) and Keio University (Japan) have presented a practicable and reliable way to test for infectious diseases in Angewandte Chemie. The simple technique uses ...
In an extension of research published a month ago in Nature Methods, a novel hybrid approach performed by researchers from Clemson University's department of physics and astronomy and Stony Brook University has revealed a ...
Splitting up and getting back together is always hard to do, but for proteins, it's almost impossible.
A new method enables non-invasive monitoring of oxygen metabolism in cells that are 3-D bioprinted into complex living structures. This could contribute to studies of cell growth and interactions under tissue-like conditions, ...
Many microbes have an enzyme that can convert carbon dioxide to carbon monoxide. This reaction is critical for building carbon compounds and generating energy, particularly for bacteria that live in oxygen-free environments.
Super-resolution microscopy is a technique that allows researchers to see beyond the diffraction limit of light. The technique has garnered increasing interest, especially since its developers won the Nobel Prize in Chemistry ...
Researchers have developed fluorescent proteins that can be controlled by orange and green light. These proteins will help to study processes in living cells. Results were published in Nature Methods.
Infections with Salmonella bacteria, often caused by eating or handling undercooked meat or eggs, affect about 100 million people a year worldwide. The suffering the infection causes—abdominal cramps, fever and diarrhea—is ...
More than 230 million invasive surgeries are performed worldwide each year – and nearly all of those procedures create additional tissue damage from stitches and staples. Researchers at Purdue University are hoping to significantly ...
Why some biopharmaceuticals have a longer shelf life than others is a problem that has baffled scientists and manufacturers alike. Even the same medication, produced by different manufacturers, can vary in its storage life.
Researchers at Ruhr-Universität Bochum and the University of Tübingen have gained new insights into the structure of the killer protein Bax. The protein induces programmed cell death, the method by which the body disposes ...
New research for the first time reveals the three-dimensional structure of a membrane channel that's critical in controlling blood pressure.
When designing flying vehicles, there are many aspects of which we can be certain but there are also many uncertainties. Most are random, and others are just not well understood. University of Illinois Professor Harry Hilton ...
Many semiconductor fabricators and research labs are under increasing pressure from, of all things, vacuum. These facilities need to remove greater amounts of gas molecules and particles from their setups as new technologies ...
Magnetic forces ripple throughout the universe, from the fields surrounding planets to the gasses filling galaxies, and can be launched by a phenomenon called the Biermann battery effect. Now scientists at the U.S. Department ...
A new study by researchers at The Australian National University (ANU) could help us understand how our planet was formed.
A trio of economists is suggesting that it is time to add a well-being index to national economic measures. Carol Graham with the Brookings Institution, Kate Laffan with the London School of Economics and Sergio Pinto with ...
China is planning to launch its own 'artificial moon' by 2020 to replace streetlamps and lower electricity costs in urban areas, state media reported Friday.
A pair of researchers, one with the University of Bonn, the other the University of California, has found evidence that shows gender preferences differ more in countries that are more affluent and gender equal than in countries ...
A research group at the Center for Multidimensional Carbon Materials, within the Institute for Basic Science (IBS), has published an article in Science describing a new method to convert inexpensive polycrystalline metal ...
Almost all galaxy clusters experience mergers. While a merger takes place, a specific spiral pattern can often be observed in X-ray images. Such a spiral feature is due to the motion of the sloshing gas induced by a merger. ...
Climate change is in full swing and will continue unabated as long as CO2 emissions continue. One possible solution is to return CO2 to the energy cycle: CO2 could be processed with water into methanol, a fuel that can be ...
Most of us would acknowledge that family members often resemble one another, particularly in the face. Indeed, humans are good at picking out pairs of close relatives amongst the faces of unfamiliar adults. We are also more ...
Researchers from the University of Luxembourg, Technische Universität Berlin, and the Fritz Haber Institute of the Max Planck Society have combined machine learning and quantum mechanics to predict the dynamics and atomic ...
The ability to translate the genetic code into proteins is an essential step in all living organisms. A cornerstone of this molecular process is the ability of transfer RNA (tRNA) molecules to couple recognition of the genetic ...
What do watermelons and bacteria have in common? Just like the tasty fruit, microbes can be molded into unusual shapes, a study in Nature Communications has shown. The paper, produced by researchers at the Okinawa Institute ...
Chlorophyll is the pigment used by all plants for photosynthesis. There are two versions, chlorophyll a and chlorophyll b. These are structurally very similar to one another but have different colors, blue-green and yellowish ...
Scientists studying a valuable, but vulnerable, species of poplar have identified the genetic mechanism responsible for the species' inability to resist a pervasive and deadly disease. Their finding, published in the Proceedings ...
A newly discovered toxin that some bacteria deploy to fend off competing bacteria stands out from others in the battle for microbial domination. While many deadly substances have been identified among bacteria, this previously ...
The word "HAZMAT" describes substances that pose a risk to the environment, or even to life itself. Imagine the term being applied to entire planets, where violent flares from the host star may make worlds uninhabitable by ...
A team of scientists led by Professor Richard Layfield at the University of Sussex has published breakthrough research in molecule-based magnetic information storage materials.
A two-year cycle in the gamma-ray brightness of a blazar, a galaxy powered by a supermassive black hole, has been confirmed by 10 years of observations from NASA's Fermi Gamma-ray Space Telescope. The findings were announced ...
Inside smartphones and computer displays are metals known as the rare earths. Mining and purifying these metals involves waste- and energy-intense processes. Better processes are needed. Previous work has shown that specific ...
An international team of researchers has successfully produced a Bose-Einstein condensate (BEC) in space for the first time. In their paper published in the journal Nature, the group describes creating a small experimental ...
New observations by two Arizona State University astronomers using the Hubble Space Telescope have caught a red dwarf star in a violent outburst, or superflare. The blast of radiation was more powerful than any such outburst ...
Measuring the properties of superconducting materials in magnetic fields at close to absolute zero temperatures is difficult, but necessary to understand their quantum properties. How cold? Lower than 0.05 Kelvin (-272°C).
Those pesky bees that come buzzing around on a muggy summer day are helping researchers reveal the genes responsible for social behaviors. A new study published this week found that the social lives of sweat bees—named ...
A new paper written by academics at Royal Holloway and George Washington University, predicts reliable patterns in violent events occurring within wars and terrorism, regardless of geography, ethnicity and religion.
A team of researchers affiliated with several institutions in the U.S. has come up with a new type of cermet that could prove especially useful as a heat exchanger in solar power plants. In their paper published in the journal ...
The embryonic stem cells that form facial features, called neural crest cells, use an unexpected mechanism of moving from the back of the head to the front to populate the face, finds a new UCL-led study.
Researchers at the Center for Quantum Nanoscience (QNS) within the Institute for Basic Science (IBS) in South Korea have made a major scientific breakthrough by detecting the nuclear magnetism, or "nuclear spin" of a single ...
Scientists at Oregon State University have shed light on the evolutionary history of a soil-borne bacteria that is so dangerous to grazing animals it is kept behind lock-and-key to prevent its spread.
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