News tagged with dna damage

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Controls of specialization unraveled

Two phases of the cell cycle of human embryonic stem cells have been shown, for the first time, to actively employ pathways that maintain pluripotency—the potential to develop into almost any type of cell in the body.

dateNov 04, 2015 in Cell & Microbiology
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New functions for chromatin remodelers

Large molecular motors consisting of up to a dozen different proteins regulate access to the genome, which is essential for the transcription of genes and for the repair of DNA damage. Susan Gasser and her team now reveal ...

dateAug 28, 2014 in Cell & Microbiology
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Repairing DNA lesions

Repair of DNA lesions is essential for mammalian development. Notably, DNA lesions in cells caused by genotoxic agents results in arrest of cell cycle and ultimately in cell death. In response, DNA polymerase ζ (Polζ) is ...

dateJun 25, 2014 in Biochemistry
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