Surgical glue

Dec 03, 2007

In a few years’ time, instead of fiddling with needle and thread, sur-geons may simply use glue to connect implants to living tissue. They took their idea from mussels, which can stick to any surface, be it porous rock or the smooth hull of a ship.

It sounds like a venturous plan: Implants such as artificial heart valves and vessels are to be welded to the body’s own tissue using a special glue, completely obviating the need for bothersome sutures. The bond will be rapidly hardened by UV light, so that only 30 seconds later, the foreign object is firmly implanted in the patient’s body.

Dr. Klaus Rischka, a chemist at the Fraunhofer Institute for Manufacturing Engineering and Applied Materials Research IFAM in Bremen, is confident that this scenario will soon become reality. In the course of this award-winning project, the Fraunhofer researcher and his partners at Frankfurt University Hospital, the Center of Biotechnical Engineering BitZ at Darmstadt University of Technology, the State Materials Testing Institute MPA and the implant manufacturer Straumann in Freiburg will initially demonstrate the glue’s suitability on the basis of a dental implant made of titanium.

It is current practice to anchor tooth implants in the jaw bone without an adhesive. This often leaves gaps between the gums and the metal, allowing bacteria to enter and cause infections. A glue that firmly connects the gums to the implant would serve as an effective barrier against aggressive germs. Conventional products are not suited to such a purpose, however, as they would sooner or later dissolve in the moist environment inside the mouth.

Mussels have provided the Fraunhofer experts with a solution: Over the course of evolution, these mollusks have developed a special glue that not only works under water, but is also a particularly firm and lasting bonding agent. The strength of the bond is due to a particular protein. Chemists at IFAM are able to synthetically reproduce the key elements of the substance, and have already used them in a joint project with the European Space Agency ESA to develop an adhesive intended for everyday repairs in manned spaceflight.

The use of this substance in medical applications requires an additional ingredient: a growth protein, which can likewise be synthetically produced using the classic technique of solid-phase peptide synthesis. Its purpose is to stimulate cell growth so that the body’s own tissue – in this case the gums – bonds as closely as possible with the implant.

A third component, in the form of a classic polymer, is then added as a carrier substance. Over the next two years, the participating chemists, medics and engineers intend to create a basis for practical applications. According to Rischka, it may then take another five to ten years before the glue is ready to be used on humans.

Source: Fraunhofer-Gesellschaft

Explore further: Water leads to chemical that gunks up biofuels production

add to favorites email to friend print save as pdf

Related Stories

Nature's strongest glue comes unstuck

Jul 18, 2014

Over a 150 years since it was first described by Darwin, scientists are finally uncovering the secrets behind the super strength of barnacle glue.

New method to test materials can aid national defense

Mar 20, 2013

A report on research exploring ways to characterize the internal structure, properties and behavior of advanced materials used in challenging Department of Defense operations has won three Arizona State University engineers ...

Sugary band-aid may help heal post-operative tissue

May 31, 2010

A compound found in sunless tanning spray may help to heal wounds following surgery, according to new results published by plastic surgeons from NewYork-Presbyterian Hospital/Weill Cornell Medical Center in New York City ...

Recommended for you

Water and sunlight the formula for sustainable fuel

2 hours ago

An Australian National University (ANU) team has successfully replicated one of the crucial steps in photosynthesis, opening the way for biological systems powered by sunlight which could manufacture hydrogen ...

Rice chemist wins 'Nobel Prize of Cyprus'

2 hours ago

Rice University organic chemist K.C. Nicolaou has earned three prestigious international honors, including the Nemitsas Prize, the highest honor a Cypriot scientist can receive and one of the most prestigious ...

Researchers create engineered energy absorbing material

4 hours ago

(Phys.org) —Materials like solid gels and porous foams are used for padding and cushioning, but each has its own advantages and limitations. Gels are effective as padding but are relatively heavy; gel performance ...

Solar fuels as generated by nature

4 hours ago

(Phys.org) —Society's energy supply problems could be solved in the future using a model adopted from nature. During photosynthesis, plants, algae and some species of bacteria produce sugars and other energy-rich ...

New tool identifies therapeutic proteins in a 'snap'

4 hours ago

(Phys.org) —In human and bacterial cells, glycosylation – the chemical process of attaching complex sugar molecules to proteins – is as fundamental as it gets, affecting every biological mechanism from cell signaling ...

User comments : 0