Research news on Immune Evasion

Immune evasion is a biological process by which pathogens, tumor cells, or other aberrant cells avoid detection, recognition, or elimination by the host immune system, thereby promoting persistence and proliferation. Mechanisms include antigenic variation, downregulation or loss of major histocompatibility complex (MHC) molecules, expression of immune checkpoint ligands (e.g., PD-L1), secretion of immunosuppressive cytokines, induction of regulatory T cells or myeloid-derived suppressor cells, and shielding of antigens within biofilms or physical barriers. This process critically influences infection chronicity, tumor progression, vaccine efficacy, and the outcome of host–pathogen or host–tumor coevolution.

Hidden tick saliva protein may help stop disease spread at source

Few creatures inspire as much universal dislike as ticks. Though small, these parasites have an enormous impact on human and animal health. Each year, ticks spread viruses and bacteria that infect people, livestock, wildlife, ...

This anti-CRISPR stops the protein assembly line in bacteria

Bacteria fend off invading viruses with molecular scissors that slice up viral DNA—a system called CRISPR that's become indispensable to gene editing. But viruses can fight back with a molecular trick that stops the scissors ...

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