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Researchers use ultrasound to control orientation of small particles

Researchers use ultrasound to control orientation of small particles
An image of the modeling depicts how the applied ultrasound orients nanorods in a microfluidic nozzle. Credit: Igor Aronson

Acoustic waves may be able to control how particles sort themselves. While researchers have been able to separate particles based on their shape—for example, bacteria from other cells—for years, the ability to control their movement has remained a largely unsolved problem, until now.

Using and a , Penn State researchers have separated, controlled and ejected different particles based on their shape and various properties. They published their results in the journal Small.

"We engineered a microchannel nozzle and applied ultrasound energy to the system," said corresponding author Igor Aronson, the Penn State Dorothy Foehr Huck and J. Lloyd Huck Chair Professor of Biomedical Engineering and professor of chemistry and of mathematics. "The nozzle plays two roles. It concentrates , which is something other researchers have done. But in addition to that, the walls of the nozzle reflect the acoustic waves of the ultrasound energy."

Aronson and his collaborators worked with tiny materials called nanorods, which are some of the most studied synthetic self-propelled particles, according to Aronson. Because they are a similar size and have a similar swimming speed to , Aronson said, many of the conclusions drawn from observing nanorods can be applied to bacteria movement. For this reason, they are often used as proof of concept for future separation tasks.

In this case, the nanorods were half platinum and half gold. The researchers placed the nanorods in a nozzle, shaped like a miniature syringe, and then added hydrogen peroxide. The is decomposed—or burned—on the platinum half of each nanorod, forcing them to swim in an imitation of how bacteria behave.

The researchers applied ultrasound to the nozzle, producing that, along with the flow of fluid, were able to separate the particles, aggregate them or extrude them from the nozzle.

Researchers use ultrasound to control orientation of small particles
Penn State biomedical engineering graduate student Leonardo Dominguez Rubio, left, and Penn State Dorothy Foehr Huck and J. Lloyd Huck Chair Professor of Biomedical Engineering Igor Aronson are part of a team that used ultrasound technology and a nozzle to separate, control and eject different particles based on their shape and various properties. Credit: Penn State College of Engineering

"The separation concept relies on the fact that nanorods and spherical particles have different responses to acoustic radiation and generated fluid flow," Aronson said. "By controlling the nozzle shape and the frequency and amplitude of the acoustic radiation, we can coerce particles of different shapes and material properties to behave differently. This, especially, applies to active particles such as nanorods: They can swim autonomously, and their control is especially challenging."

This level of control in separating out particles had not been demonstrated previously, according to the researchers.

Aronson said this demonstration has implications for future technologies, including additive manufacturing, also known as 3D printing, and drug delivery.

"For 3D printing, the idea is you can add certain additives to the ink—for example, nanorods," he said. "So now, we could separate nanorods from spherical to deposit only some in the printout, such as depositing polymers without nanorods and so on, all to change the property of the printout."

Aronson said this principle also applies to printing living cells, known as bioprinting.

"Potential bioprinting applications may include designing acoustic nozzles for bio-inkjet-like printers," he said. "By controlling the acoustic radiation in the nozzle, we can potentially extrude certain types of cells—for example, —and trap other types—for example, bacteria. It's an additional control for bioprints."

This capability could also be useful for separating bacteria from cells in targeted , Aronson said. The researchers next plan is to mix live bacteria and cells in a lab setting and then separate and control them.

More information: Leonardo Dominguez Rubio et al, Ultrasound Manipulation and Extrusion of Active Nanorods, Small (2023). DOI: 10.1002/smll.202300028

Journal information: Small

Citation: Researchers use ultrasound to control orientation of small particles (2023, June 16) retrieved 16 April 2024 from
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