Biomedical polymers: Synthesis, properties, and applications

Biomedical polymers have been extensively developed for promising applications in a lot of biomedical fields, such as drug delivery, disease detection/diagnosis, biosensing, regenerative medicine, and disease treatment. For ...

Bacterial enzyme makes new type of biodegradable polymer

Strings of sugars called polysaccharides are the most abundant biopolymers on Earth. Because of their versatile and environmentally friendly properties, these molecules could eventually replace some plastics. Now, researchers ...

Improving nano-particle passage through the body

A new approach to send 'friendly' nano-particles into a patient's blood stream has shown promising results by modifying the surface of these potential drug, vaccine or cancer treatment delivery objects to encourage the best ...

Could tiny devices made out of DNA treat cancer?

One of the most promising avenues in treating cancer is to restore our immune system's ability to recognize and attack cancerous cells. A team of University of Chicago chemists and biologists developed a tiny device that ...

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Drug delivery

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Drug delivery technologies are patent protected formulation technologies that modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Most common methods of delivery include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection. For example, many immunizations are based on the delivery of protein drugs and are often done by injection.

Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. Types of sustained release formulations include liposomes, drug loaded biodegradable microspheres and drug polymer conjugates.

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