Researchers plan DNA-based nanorobot for cancer diagnostics

A group of researchers from ITMO University has come up with the concept of a new drug against cancer: a nanorobot made of DNA fragments, which can potentially be used not only to destroy cancer cells, but also to locate ...

Microswimmers swim faster over slippery surfaces

Tiny self-propelling spheres, measuring only micrometers, move faster over a hydrophobic silicone surface than they do over hydrophilic glass. "Almost nobody had realized that the substrate matters," says Stefania Ketzetzi, ...

Nanocontainers for targeted drug delivery

RUDN University bioengineers have created magnetic nanocontainers for smart delivery of drugs to the desired organs or tissues, which reduces the risk of side effects. An experiment on mice determined that the nanocontainers ...

Cutting nanoparticles down to size

A new technique in chemistry could pave the way for producing uniform nanoparticles for use in drug delivery systems.

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Drug delivery

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Drug delivery technologies are patent protected formulation technologies that modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Most common methods of delivery include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection. For example, many immunizations are based on the delivery of protein drugs and are often done by injection.

Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. Types of sustained release formulations include liposomes, drug loaded biodegradable microspheres and drug polymer conjugates.

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