New technique for sorting micro-particles uses sound waves

Thanks to the rapid progress in tiny tech, we've been mainly using microfluidics to sort tiny particles by size. But now, there's a new way to sort them by shape, which could be a big deal for medical tests and chemistry. ...

Exploring the chemistry behind love this Valentine's Day

Chemistry in a relationship refers to the intense feelings of connection, passion, and romance that people share. This Valentine's Day, Dr. Alex Baker, a chemistry professor at the University of Warwick, explores the real ...

Very small pores make a big difference in filtering technology

Nanoporous membranes have been shown to be valuable tools for filtering out impurities from water and numerous other applications. However, there's still much work to be done in perfecting their designs. Recently, the lab ...

Researchers develop puffed-up MOFs for improved drug delivery

The spongelike structure of metal-organic frameworks (MOFs) allows these polymers to possibly carry and deliver a range of therapeutic compounds. Now, researchers reporting in ACS Applied Bio Materials have treated a chromium-containing ...

Going beyond plastic: Tara gum as a green polymer

Synthetic, non-biodegradable plastics are major sources of environmental pollution and have prompted rising interest in sustainable, biodegradable alternatives derived from natural polymers. "Tara gum," derived from the seeds ...

Precision coating boosts nanomedicine

A study published in the International Journal of Nanotechnology has looked at the controlled synthesis and coating of magnetic nanoparticles (MNPs), specifically using oleic acid (OA) and polyethylene glycol (PEG). These ...

On-demand conformation of an artificial cytoskeleton

Peptide nanotubes are tubular-shaped structures formed by the controlled stacking of cyclic peptide components. These hollow biomaterials show inner and outer faces, allowing control over their properties.

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Drug delivery

Drug delivery is the method or process of administering a pharmaceutical compound to achieve a therapeutic effect in humans or animals. Drug delivery technologies are patent protected formulation technologies that modify drug release profile, absorption, distribution and elimination for the benefit of improving product efficacy and safety, as well as patient convenience and compliance. Most common methods of delivery include the preferred non-invasive peroral (through the mouth), topical (skin), transmucosal (nasal, buccal/sublingual, vaginal, ocular and rectal) and inhalation routes. Many medications such as peptide and protein, antibody, vaccine and gene based drugs, in general may not be delivered using these routes because they might be susceptible to enzymatic degradation or can not be absorbed into the systemic circulation efficiently due to molecular size and charge issues to be therapeutically effective. For this reason many protein and peptide drugs have to be delivered by injection. For example, many immunizations are based on the delivery of protein drugs and are often done by injection.

Current efforts in the area of drug delivery include the development of targeted delivery in which the drug is only active in the target area of the body (for example, in cancerous tissues) and sustained release formulations in which the drug is released over a period of time in a controlled manner from a formulation. Types of sustained release formulations include liposomes, drug loaded biodegradable microspheres and drug polymer conjugates.

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