Team discovers molecular channel that regulates blood pressure

September 25, 2018, Oregon Health & Science University
Using a cryo-electron microscope, researchers at OHSU in Portland, Oregon, generated a three-dimensional model of the human epithelial sodium channel. The channel is critical in controlling blood pressure, among other functions in the body. Credit: OHSU

New research for the first time reveals the three-dimensional structure of a membrane channel that's critical in controlling blood pressure.

The findings, published today in the open-access journal eLife, represent the first time the human epithelial sodium channel has been shown so precisely since it was first isolated and described through expression cloning in 1993, said senior author Isabelle Baconguis, Ph.D., assistant professor in the OHSU Vollum Institute. Lead author Sigrid Noreng, a graduate student in the Baconguis lab, added that the discovery provides a starting point for the development of better treatments for a range of diseases associated with the channel.

"It's definitely going to move the field forward," Baconguis agreed.

The channel enables sodium ions to be absorbed into tissues throughout the body, including the kidney. As such, it is a crucial aspect of human health by regulating sodium balance, volume and .

"We wouldn't have been able to leave the ocean without it," quipped co-author Richard Posert, a in Baconguis' lab.

Dysfunction of the epithelial sodium channel, or ENaC, can lead to severe forms of hypertension such as Liddle syndrome or neonatal salt-wasting disorder. The discovery answers fundamental biophysical questions about the specific architecture of the channel, which ultimately could lead to the development of medications to improve the treatment of diseases such as severe hypertension, heart failure and nephrotic syndrome.

"This is the first visual representation of a protein that is connected to many diseases," Baconguis said. "As soon as you perturb this membrane protein, everything downstream becomes disrupted as well."

Noreng noted the discovery may be especially helpful in developing targeted medications to control .

"There are no good medications that target this protein specifically," Noreng said. "Discovering the structure of this channel will be very important toward the development of new and better blood pressure medications."

The researchers made the discovery through the use of a cryo-electron microscope housed in OHSU's Robertson Life Sciences Building. Cryo-EM technology is part of a newly designated national center intended to widen the use of a technique that is revolutionizing structural biology. The technique enables scientists to visualize biological molecules at an atomic scale and to see them in their natural state.

Explore further: How a 'jellyfish'-shaped structure relieves pressure in your cells

More information: Sigrid Noreng et al, Structure of the human epithelial sodium channel by cryo-electron microscopy, eLife (2018). DOI: 10.7554/eLife.39340

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Anoym275346n
not rated yet Sep 25, 2018
On May 18th, 2017 I started having issues with my blood pressure. The condition never got any better and on my second visit to my doctor, my meds were increased. This is when it dawned on me that my condition was deteriorating and I had to do something. With the high blood pressure, I would either suffer from a heart attack or stroke and this is something I wanted to avoid at all cost. Just when I was about to give up I came across a story online (google " How I Helped My Friend Cure Hypertension " ). The story was about how one Mary was able to manage her blood pressure. I read the story and implemented her program and I was surprised by how fast I got results. The next time I visited my doctor for a follow up my medications were reduced, I even manage to shed off some extra weight
leetennant
5 / 5 (1) Sep 26, 2018
Fuck off with your pseudoscientific snakeoil salesman bullshit.

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