A molecular hammock for cotranslational modification

Proteins do most of the real work in cells and are modified in accordance with functional requirements. An LMU team has now shown how proteins are chemically altered on the ribosome, even before they fold into the active ...

The birth and death of proteins in a single cell

The amount of proteins inside cells fluctuates over time, and this affects various functions of the cells. Cells are constantly synthesizing and degrading proteins, and studies have shown that this "see-saw" effect actually ...

Designer enzyme uses unnatural amino acid for catalysis

University of Groningen chemists have created a new enzyme with an unnatural amino acid as its active centre. They made the enzyme by modifying an antibiotic binding protein which normally acts as a bacterial transcription ...

Mechanical force controls the speed of protein synthesis

As cells create proteins, the proteins modulate synthesis speed by exerting a mechanical force on the molecular machine that makes them, according to a team of scientists who used a combination of computational and experimental ...

On building ribossomes

Ribosomes are organelles responsible for protein synthesis in all living organisms. Ribosomes are made of proteins and RNA (Ribosomal RNA, rRNA) and putting the several elements in the right location requires a precise multi-step ...

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