Related topics: protein · gene expression · rna molecules · cells · genes

Protein quality control and mitochondria

Protein aggregates are toxic for mitochondrial function, and thus disrupt the supply of chemical energy to their host cells. An LMU team has characterized a protein complex that prevents the build-up of such deposits in the ...

A study describes the reaction mechanism of DNAzymes

A study from the Institute for Research in Biomedicine (IRB Barcelona) has published a study in the journal Nature Catalysis that describes the reaction mechanism used by the DNAzyme 9DB1, the first structurally available ...

How the cell protects itself

The cell contains transcripts of genetic material, which migrate from the cell nucleus to another part of the cell. This movement protects the genetic transcripts from the recruitment of "spliceosomes." If this protection ...

Cell lesson: better coordinated than isolated

A new study led by Juana Díez, principal investigator of the Department of Experimental and Health Sciences (DCEXS) at UPF, has found a new system in cells that makes them more robust against possible alterations in the ...

Nanomachines taught to fight cancer

Scientists from ITMO in collaboration with international colleagues have proposed new DNA-based nanomachines that can be used for gene therapy for cancer. This new invention can greatly contribute to more effective and selective ...

Protein production efficiency can be predicted by gene sequence

Today, thousands of databases with biological data are publicly available. They include data on gene and protein sequences and detailed measurements of different cellular parameters, such as the exact quantities of all proteins ...

Fighting human disease with birth control ... for mosquitoes

Depending on where you live, the buzz of a nearby mosquito can be a nuisance, or it can be deadly. Worldwide, more than 500 million people suffer from diseases transmitted by the blood-feeding insects, including malaria, ...

Engineers create an inhalable form of messenger RNA

Messenger RNA, which can induce cells to produce therapeutic proteins, holds great promise for treating a variety of diseases. The biggest obstacle to this approach so far has been finding safe and efficient ways to deliver ...

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Messenger RNA

Messenger ribonucleic acid (mRNA) is a molecule of RNA encoding a chemical "blueprint" for a protein product. mRNA is transcribed from a DNA template, and carries coding information to the sites of protein synthesis: the ribosomes. Here, the nucleic acid polymer is translated into a polymer of amino acids: a protein. In mRNA as in DNA, genetic information is encoded in the sequence of nucleotides arranged into codons consisting of three bases each. Each codon encodes for a specific amino acid, except the stop codons that terminate protein synthesis. This process requires two other types of RNA: transfer RNA (tRNA) mediates recognition of the codon and provides the corresponding amino acid, while ribosomal RNA (rRNA) is the central component of the ribosome's protein manufacturing machinery.

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