Related topics: genes · cells · protein · genome · cancer cells

Does rearranging chromosomes affect their function?

Molecular biologists have long thought that domains in the genome's 3-D organization control how genes are expressed. After studying highly rearranged chromosomes in fruit flies, EMBL researchers now reveal that while this ...

Biologists design a plug-and-play controller for gene expression

Researchers from two University of Texas System institutions have engineered biological components that can rewire genetic response pathways, creating a template for designing new cellular behaviors with wide-ranging potential ...

Networks of gene activity control organ development

For the first time, researchers have decoded the genetic programmes that control the development of major organs in humans and other selected mammals—rhesus monkeys, mice, rats, rabbits and opossums—before and after birth. ...

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Gene expression

Gene expression is the process by which information from a gene is used in the synthesis of a functional gene product. These products are often proteins, but in non-protein coding genes such as rRNA genes or tRNA genes, the product is a functional RNA.

Several steps in the gene expression process may be modulated, including the transcription, RNA splicing, translation, and post-translational modification of a protein. Gene regulation gives the cell control over structure and function, and is the basis for cellular differentiation, morphogenesis and the versatility and adaptability of any organism. Gene regulation may also serve as a substrate for evolutionary change, since control of the timing, location, and amount of gene expression can have a profound effect on the functions (actions) of the gene in the organism.

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