Landing therapeutic genes safely in the human genome

Many future gene and cell therapies to treat diseases like cancer, rare genetic and other conditions could be enhanced in their efficacy, persistence, and predictability by so-called "genomic safe harbors (GSHs)." These are ...

Modeling how cells choose their fates

It may seem hard to believe, but each one of us began as a single cell that proliferated into the trillions of cells that make up our bodies. Though each of our cells has the exact same genetic information, each also performs ...

Natural killer cells coordinate wound healing

Natural killer cells do not just kill cancer cells or cells infected with viruses, they also mediate a trade-off between wound healing and bacterial defense in skin wounds. If the healing process is accelerated, the immune ...

How cells remember inflammation

When a tissue experiences inflammation, its cells remember. Pinning proteins to its genetic material at the height of inflammation, the cells bookmark where they left off in their last tussle. Next exposure, inflammatory ...

Basement membrane underpins tissue interactions in the skin

In a discovery that could pave the way for therapies that promote wound healing and alleviate skin diseases, RIKEN researchers have found that the network of molecules under the outermost layer of mouse skin, the skin epithelium, ...

AI spots healthy stem cells quickly and accurately

Stem cell therapy is at the cutting edge of regenerative medicine, but until now researchers and clinicians have had to painstakingly evaluate stem cell quality by looking at each cell individually under a microscope. Now, ...

Understanding the skin's defense system

It can be easy to forget that the human skin is an organ. It's also the largest one and it's exposed, charged with keeping our inner biology safe from the perils of the outside world.

Researchers create "Ancestry.com" for cells

One of great mysteries of human biology is how a single cell can give rise to the 37 trillion cells contained in the average body, each with its own specialized role. Researchers at Yale University and the Mayo Clinic have ...

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