Early breeding reduced harmful mutations in sorghum

Early breeding reduced harmful mutations in sorghum
The image shows variation in seed head architecture of the different sorghum races, including (from left to right) bicolor, guinea, caudatum, kafir and durra. Credit: Nadia Shakoor/Provided

When humans first domesticated maize some 9,000 years ago, those early breeding efforts led to an increase in harmful mutations to the crop's genome compared to their wild relatives, which more recent modern breeding has helped to correct.

A new comparative study investigates whether the same patterns found in maize occurred in sorghum, a gluten-free grain grown for both livestock and human consumption. The researchers were surprised to find the opposite is true: Harmful in sorghum landraces (early domesticated crops) actually decreased compared to their wild relatives.

The study, "Comparative Evolutionary Genetics of Deleterious Load in Sorghum and Maize," published Jan. 15 in Nature Plants. The senior author is Michael Gore, professor of molecular breeding and genetics in the College of Agriculture and Life Sciences (CALS).

The research may inform future breeding efforts in both sorghum and maize.

"We assumed that maize and sorghum would have complementary patterns of deleterious mutations, because all the work that has been done in crops up to this point has shown an increase in deleterious burden in domesticates compared to wild relatives from which crops originate," Gore said. "But sorghum does not follow this pattern and it's very surprising."

These "deleterious mutations," which potentially have a on the fitness of an organism, result from random genetic errors that occur every generation, and from ancient mutations that may be linked to beneficial genetic variants selected during crop domestication and improvement.

In the study, the researchers ran population genetics simulations to help explain why sorghum failed to follow the same pattern found in maize.

One major difference between maize and sorghum is that maize (wild and domesticated) is an "outcrosser," meaning its (ear shoots) are predominantly pollinated by other maize plants; domesticated sorghum is a "selfer," meaning the flowers of its panicles (heads) are mostly fertilized by each plant's own pollen.

It turns out that sorghum's wild relatives have more open seed heads that facilitate outcrossing. But in the process of sorghum domestication, the panicles that hold these clusters of flowers became more compact, which increased "selfing" rates.

"We posit that the alteration of panicle morphology impacted deleterious mutation patterns in sorghum," Gore said. "The resultant increase in selfing likely contributed to the purging of deleterious mutations after domestication."

By understanding the historical patterns of , breeders may use that knowledge to better purge deleterious mutations from sorghum . "What we're learning in could also be applied to and vice versa," Gore said.


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More information: Roberto Lozano et al, Comparative evolutionary genetics of deleterious load in sorghum and maize, Nature Plants (2021). DOI: 10.1038/s41477-020-00834-5
Journal information: Nature Plants

Provided by Cornell University
Citation: Early breeding reduced harmful mutations in sorghum (2021, January 21) retrieved 26 February 2021 from https://phys.org/news/2021-01-early-mutations-sorghum.html
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