Like thread tightly wrapped around a spool, DNA is wrapped around histones and packaged into structures called nucleosomes. Scientists at St. Jude Children's Research Hospital are exploring how a type of transcription factor ...
Cell & Microbiology
May 24, 2023
0
137
Plants show enormous variety in traits relevant to breeding, such as plant height, yield and resistance to pests. One of the greatest challenges in modern plant research is to identify the differences in genetic information ...
Molecular & Computational biology
May 19, 2023
0
6
For the first time, researchers from Tel Aviv University have developed a genome-scale technology that makes it possible to reveal the role of genes and traits in plants previously hidden by functional redundancy.
Biotechnology
May 15, 2023
0
184
Have you ever wondered why some people might get sicker than others, even when they catch the same virus? It is not yet clear why this is. Viral factors (such as differences in the strain of a virus) play a role in this variability, ...
Cell & Microbiology
May 12, 2023
0
78
A research group at the University of Cordoba characterizes a new transcription factor that regulates, during the ripening of strawberries, the production of anthocyanins responsible for giving them their red hue.
Molecular & Computational biology
May 9, 2023
1
17
Exploring the upstream transcription factors or proteins interacting with MdMYB10 is an important way to enrich the complex network of anthocyanin synthesis.
Molecular & Computational biology
Apr 24, 2023
0
3
New insight into proteins called "pioneer factors" helps to explain their unusual ability to open up the typically dense genetic material within our cells. This behavior makes the genetic material accessible for proteins ...
Cell & Microbiology
Apr 20, 2023
0
20
New research has revealed important information about how aspirin works. Even though this drug has been available commercially since the late 1800s, scientists have not yet fully elucidated its detailed mechanism of action ...
Biochemistry
Mar 28, 2023
0
30
A new study has revealed insights into how cells sense and respond to the weightlessness experienced in space. The information could be useful for keeping astronauts healthy on future space missions.
Cell & Microbiology
Mar 28, 2023
0
7
Recently, a team led by Prof. Qu Kun from the University of Science and Technology (USTC) of the Chinese Academy of Sciences (CAS) in collaboration with a team led by Prof. Wang Zhikai from the Hefei National Laboratory for ...
Cell & Microbiology
Mar 15, 2023
0
21
In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the transfer (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme which performs the transcription of genetic information from DNA to RNA) to specific genes.
A defining feature of transcription factors is that they contain one or more DNA binding domains (DBDs) which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA binding domains, and therefore are not classified as transcription factors.
This text uses material from Wikipedia, licensed under CC BY-SA
