Related topics: genes · cells · gene expression · stem cells · dna sequences

Researchers construct dynamic landscape of medaka embryogenesis

Medaka, a fish, has become an important vertebrate model widely used in genetics, developmental biology, environmental sciences, and many other fields. A high-quality genome sequence and a variety of genetic tools are available ...

A genome-scale map of DNA methylation kinetics

While the first genome-wide DNA methylation map in mammalian cells was established over 10 years ago, such maps only provide snapshots and do not inform about the actual dynamics of this epigenetic mark. Researchers from ...

Researchers unlock genomic secrets of scaly-foot snail

Despite an extreme environment characterized by high pressure, high temperature, strong acidity and low oxygen levels resembling living conditions in prehistoric times, hydrothermal vents harbor a diverse population of creatures, ...

OsFIT and OsIRO2 interact to regulate iron homeostasis in rice

Iron (Fe) is necessary for plant growth and development because it is involved in many physiological and biochemical reactions. Fe deficiency can cause serious agricultural problems. It is well known that Fer‐like Fe deficiency‐induced ...

Researchers move closer to producing heparin in the lab

In a recent study published in the Proceedings of the National Academy of Sciences (PNAS), University of California San Diego researchers moved one step closer to the ability to make heparin in cultured cells. Heparin is ...

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Transcription factor

In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the transfer (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme which performs the transcription of genetic information from DNA to RNA) to specific genes.

A defining feature of transcription factors is that they contain one or more DNA binding domains (DBDs) which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA binding domains, and therefore are not classified as transcription factors.

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