The central dogma of molecular biology postulates that the information packets encoded within the molecules of deoxyribonucleic acid (DNA) are first transcribed into molecules of messenger ribonucleic acids (mRNAs), and then ...
Aldehydes are toxic compounds that are produced in the body by metabolic processes, especially upon alcohol consumption. They are dangerous because they bind to cellular macromolecules, such as DNA, RNA, and proteins, and ...
Cell & Microbiology
Nov 15, 2023
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9
A first-ever, atom-by-atom supercomputer simulation shows how antibiotics kill bacteria and illustrates other processes of the molecular machinery in living cells. The research opens fresh pathways to improving antibiotics, ...
Cell & Microbiology
Sep 20, 2023
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5
Bacteria are nearly ubiquitous and have tremendous impacts on human and ecological health. And yet, they remain largely mysterious to us. Princeton MOL faculty Zemer Gitai, Britt Adamson and Ned Wingreen launched a joint ...
Cell & Microbiology
Sep 14, 2023
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20
Bacteria draw from an arsenal of weapons to combat the drugs intended to kill them. Among the most prevalent of these weapons are ribosome-modifying enzymes. These enzymes are growing increasingly common, appearing worldwide ...
Biotechnology
Aug 14, 2023
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8
Myelotoxicity is the primary dose-limiting effect of the commonly used chemotherapeutic agent 5-fluorouracil (5-FU), which may endanger the life of the patient. Ribosome biogenesis is a key pathway regulating hematopoietic ...
Cell & Microbiology
Aug 8, 2023
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5
The mechanisms of RNA-binding proteins (RBPs)-mediated post-transcriptional regulation of pre-existing mRNAs, which is essential for spermatogenesis, remain poorly understood.
Cell & Microbiology
Jul 25, 2023
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1
The human body consists of trillions of cells, and 60% of the energy used within a cell is dedicated to a specific molecular machine. That machine is responsible for producing proteins, which are fundamental building blocks ...
Cell & Microbiology
Jul 21, 2023
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22
Life runs on ribosomes. Every cell on Earth needs ribosomes to translate genetic information into all the proteins needed for the organism to function—and to in turn make more ribosomes. But scientists still lack a clear ...
Cell & Microbiology
Jul 6, 2023
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402
All biological processes in our cells are constantly monitored to prevent the accumulation of defective proteins. In the worst case, such protein clumps can trigger diseases. The synthesis of new proteins is particularly ...
Cell & Microbiology
Jun 20, 2023
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