Transmembrane β-barrel pores (TMBs) are extensively used for single-molecule DNA and RNA sequencing. They enable the miniaturization of a wide array of sensing and sequencing applications into portable USB-size devices and ...
Bio & Medicine
Jul 18, 2024
0
103
Many drug and antibody discovery pathways focus on intricately folded cell membrane proteins: when molecules of a drug candidate bind to these proteins, like a key going into a lock, they trigger chemical cascades that alter ...
Biotechnology
Jun 21, 2024
0
39
Multicellular organisms, like animals and plants, have complex cells with diverse functions. This complexity arises from the need for cells to produce distinct proteins that interact with each other. This interaction is crucial ...
Biochemistry
May 23, 2024
0
66
Scientists have developed DIProT, an innovative, user-friendly toolkit for protein design. The toolkit utilizes a non-autoregressive deep generative model to address the protein inverse folding problem, integrating human ...
Biotechnology
May 20, 2024
0
1
Many important medicines, such as antibiotics and anticancer drugs, are derived from natural products of bacteria. The enzyme complexes that produce these active ingredients have a modular design that makes them ideal tools ...
Cell & Microbiology
Mar 21, 2024
0
51
In the wake of the COVID-19 pandemic, scientists have been racing to develop effective treatments and preventatives against the virus. A recent scientific breakthrough has emerged from the work of researchers aiming to combat ...
Biotechnology
Mar 14, 2024
0
157
David Baker's group at the University of Washington, Seattle, U.S., have developed a novel deep learning method, RoseTTAFold All-Atom (RFAA), for prediction and design of complexes of proteins, small molecules, and nucleic ...
Biotechnology
Mar 11, 2024
0
1
Researchers at the University of Toronto have used an artificial intelligence framework to redesign a crucial protein involved in the delivery of gene therapy.
Biotechnology
Jan 29, 2024
0
116
Designed to meet the urgent need for insights into the molecular intricacies of SARS-CoV-2 infection, BioExcel-CV19 is a repository for molecular dynamics (MD) simulations.
Molecular & Computational biology
Jan 8, 2024
0
49
This study was led by Prof. Wen-Bin Zhang (College of Chemistry and Molecular Engineering, Peking University & Beijing Academy of Artificial Intelligence) and Dr. Jing Fang (College of Chemistry and Molecular Engineering, ...
Cell & Microbiology
Dec 29, 2023
0
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