First mouse model with mitochondrial tRNALeu mutation developed

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the necessary mitochondrial ...

Cellular mechanism that allows stem cells to maintain their state

Embryonic stem cells can give rise to every cell type in the body. A team of researchers from Sweden, in collaboration with groups in Switzerland and Canada, has now identified a cellular mechanism that is important for the ...

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Neurodegenerative disease

Neurodegenerative disease (Greek νέυρο-, néuro-, "nerval" and Latin dēgenerāre, "to decline" or "to worsen") is a condition in which cells of the brain and spinal cord are lost. The brain and spinal cord are composed of neurons that do different functions such as controlling movements, processing sensory information, and making decisions. Cells of the brain and spinal cord are not readily regenerated en masse, so excessive damage can be devastating. Neurodegenerative diseases result from deterioration of neurons or their myelin sheath which over time will lead to dysfunction and disabilities resulting from this.

Some sources limit the term "degenerative" to conditions primarily affecting gray matter that are not associated with a obvious inciting event.

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