A multinational research team led by Dr. Adnan Sljoka (RIKEN), Prof. R. Scott Prosser (Univ. of Toronto) with collaborations with Dr. Duy Phuoc Tran and Prof. Akio Kitao (Tokyo Tech) and Prof. Roger K. Sunahara (Univ. of ...
Cell & Microbiology
Mar 19, 2021
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9
Dr. Guangyu Wu is dissecting the molecular homing that enables a nascent protein to ultimately find its way to the surface of a cell as a mature receptor type that helps us taste, smell and even regulate our mood and immunity.
Molecular & Computational biology
Oct 14, 2020
0
56
G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in our cells, involved in signal transmission across the cell membrane. One of the biggest questions is how a signal recognized at the extracellular ...
Cell & Microbiology
Sep 9, 2014
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1
Drug development is currently an extremely long, expensive and inefficient process. Findings generated in a lab are often very hard to replicate once translated into animal models or in humans.
Biotechnology
Feb 26, 2024
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21
An international team of researchers has succeeded in "filming" the activation of an important receptor. They froze the involved molecules at different points in time and photographed them under the electron microscope. They ...
Molecular & Computational biology
Mar 13, 2024
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76
Biosensors—sensors that can detect biological samples—are powerful tools for understanding the function, composition, and structure of biochemical molecules. Biosensors are often applied for the detection of proteins ...
Cell & Microbiology
Apr 25, 2023
0
38
A team of scientists led by the iHuman Institute of ShanghaiTech University has determined and analyzed the cryo-electron microscopy structures of human bitter taste receptor TAS2R46 complexed with G protein, in both strychnine-bound ...
Cell & Microbiology
Sep 15, 2022
1
22
A group of researchers at University of California San Diego has identified the cause of a "short-circuit" in cellular pathways, a discovery that sheds new light on the genesis of a number of human diseases.
Cell & Microbiology
Jun 4, 2024
0
81
G-protein coupled receptors (GPCRs) are the "inbox" of environmental messages in mammalian cells. Because of their central role in signaling pathways, mutations resulting in abnormal GPCR functions cause a wide variety of ...
Molecular & Computational biology
Apr 15, 2019
0
7
Heterotrimeric G proteins are important in G protein-coupled receptor signaling, which plays many roles in the detection of various environmental stimuli, including hormones, neurotransmitters, light, smells, and chemical ...
Cell & Microbiology
Nov 26, 2018
0
35
