Scientists at St. Jude Children's Research Hospital and Columbia University/New York State Psychiatric Institute are studying G protein-coupled receptors (GPCRs), membrane proteins that are the target of one-third of approved ...
Cell & Microbiology
Apr 27, 2022
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24
Researchers at the Ruhr Universität Bochum have developed a new method for attaching proteins to the surface of germanium crystals – for the first time also membrane proteins. This enables time-resolved tracking of the ...
Materials Science
Mar 8, 2013
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0
Scientists at St. Jude Children's Research Hospital and the University of Texas Southwestern Medical Center studied the structure and function of a transporter involved in cancer and immunity. They captured six structures ...
Cell & Microbiology
May 23, 2023
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83
G protein-coupled receptors (GPCRs) play a crucial role in cell signal transduction and comprise the largest drug target protein family. Despite recent breakthroughs in structural and pharmacological studies of these receptors, ...
Cell & Microbiology
Apr 20, 2022
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65
Hormones and other neurotransmitters, but also drugs, act upon receptors. "Their active substances bind to the receptors and modify the three-dimensional receptor arrangement regulating the downstream signal pathways," says ...
Biochemistry
Sep 6, 2018
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5
Understanding the family of cellular on/off switches known as G-proteins is important because these proteins control a lot of the communication between cells in the human body and beyond. A new study from the University of ...
Cell & Microbiology
Oct 21, 2022
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2
A new imaging technique developed by scientists at Columbia University Vagelos College of Physicians and Surgeons and St. Jude Children's Research Hospital captures movies of receptors on the surface of living cells in unprecedented ...
Molecular & Computational biology
Apr 23, 2021
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13
In a structural analysis that could help inform efforts to develop new drugs for treating a myriad of diseases, RIKEN biologists have shed light on how the interaction between key signaling proteins and their regulatory partners ...
Cell & Microbiology
Mar 15, 2022
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37
