Understanding key enzyme's role in embryonic development

The catalytic activity of an enzyme called Set1A—a protein that is essential to the viability of embryonic stem cells (ESCs)—is not required for ESC self-renewal, according to a Northwestern Medicine study published in ...

A biobank of reversible mutant embryonic stem cells

Scientist at IMBA developed a biobank of revertible, mutant embryonic stem cells, published in the current issue of Nature. This cell bank – called Haplobank - contains over 100,000 mutated, conditional mouse embryonic ...

A new role for insulin as a vital factor in maintaining stem cells

New research conducted at the stem cell centre, DanStem, at the University of Copenhagen shows that insulin is a key determinant of embryonic stem cell potency in mammals. When large amounts of Insulin are around, stem cells ...

Glycosylation—mapping uncharted territory

Whereas major inroads have been made into genomics, metabolomics, or protein and lipid research, glycosylation remains largely unexplored at the proteome scale. There are limited technologies for profiling the complex glycoproteome. ...

Understanding the language of cellular communication

A team of Caltech scientists has uncovered a molecular code that cells use to communicate with each other. This "language" is thought to be common to many types of cellular communication and has implications for designing ...

The protein TAZ sends 'mixed signals' to stem cells

Just as beauty exists in the eye of the beholder, a signal depends upon the interpretation of the receiver. According to new USC research published in Stem Cell Reports, a protein called TAZ can convey very different signals—depending ...

What makes stem cells into perfect allrounders

Researchers from the University of Zurich and the University Hospital Zurich have discovered the protein that enables natural embryonic stem cells to form all body cells. In the case of embryonic stem cells maintained in ...

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