This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's credibility:


peer-reviewed publication

trusted source


Novel filter uses carbon nanotubes to create new paradigm for dialysis membranes

Research team reimagines kidney dialysis by creating new paradigm for dialysis membranes
Wafer-scale vertically aligned carbon nanotubes (CNT) integrated into a membrane platform comprising sub-5 nm channels/capillaries enable overcoming persistent challenges in hemofiltration/hemodialysis. Compared with conventional membranes, CNT membranes allow for greatly enhanced removal of middle molecules (≈15–60 kDa) while maintaining comparable albumin (≈66 kDa) retention and significantly higher hydraulic permeability (more than an order of magnitude when normalized to pore-area). Credit: Cheng, Ferrell, et al

A collaborative team has developed a new type of filter for kidney dialysis machines that can clean the blood more efficiently and improve patient care. Piran Kidambi, assistant professor of chemical and biomolecular engineering, led the team, which included William Fissell, associate professor of nephrology and hypertension at Vanderbilt University Medical Center, Shuvo Roy, professor of bioengineering at University of California, San Francisco, and Francesco Fornasiero, biosciences and biotechnology staff scientist at Lawrence Livermore National Lab.

Chronic kidney disease, a condition where kidney damage results in poor blood filtration, affects approximately 697.5 million people—or 9% of the global population. Treatment includes hemofiltration, hemodialysis or kidney transplantation. Hemofiltration and hemodialysis support the kidneys by filtering toxins and from blood.

The new filter uses carbon nanotubes—tiny tubes formed by a sheet of carbon atoms bonded in a hexagonal honeycomb mesh structure—that have very small, smooth channels. These channels make it easier to remove toxins and waste from the blood without letting important proteins escape, which can be a problem with traditional filters.

In the article "High-Performance Hemofiltration via Molecular Sieving and Ultra-Low Friction in Carbon Nanotube Capillary Membranes," published in the journal Advanced Functional Materials on Aug. 27, Kidambi and his co-authors demonstrate that their dialysis membranes made up of carbon nanotubes and polymers create a new paradigm for dialysis.

"Our membranes outperform state-of-the-art dialysis membranes by more than an order of magnitude while simultaneously allowing for enhanced removal of middle molecules that could cause toxicity and other ," Kidambi said. "We showed that precise control of diameters not only allowed for enhanced and effective removal of middle molecules, but the straight channel geometry as well as slippery walls of the nanotubes allowed for significantly enhanced flow."

The work also yielded fundamental insights on how biomolecules transport in nanoscale constrictions. Like an octopus that can contort itself to fit in the smallest spaces and then expand, Kidami and his co-authors discovered that biomolecules squeeze into the entrance of the nanotube in the , travel through it and expand again on the other side. This knowledge can help researchers and engineers design membranes for biological separations beyond dialysis.

Using better membranes in dialysis is beneficial for patient care. Kidambi and his colleagues plan to assess long-term operational feasibility, blood compatibility and other questions about the filter to develop it for . They aim to further this technology with advances the Kidambi lab has made in graphene.

"Our goal is to enable smaller kits for dialysis so they can go to patients, instead of them coming to the hospital and getting strapped into a machine three times a week for four hours," said Peifu Cheng, a postdoctoral research associate in the Kidambi lab and the paper's first author. "That would be a huge improvement in the quality of life of the patient. Our long-term goal is to move toward implantable devices."

More information: Peifu Cheng et al, High‐Performance Hemofiltration via Molecular Sieving and Ultra‐Low Friction in Carbon Nanotube Capillary Membranes, Advanced Functional Materials (2023). DOI: 10.1002/adfm.202304672

Journal information: Advanced Functional Materials

Citation: Novel filter uses carbon nanotubes to create new paradigm for dialysis membranes (2023, September 21) retrieved 6 December 2023 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Researchers develop a better membrane for dialysis machines


Feedback to editors