Molecular tweezers that attack antibiotic resistant bacteria

Molecular tweezers that attack antibiotic resistant bacteria developed by Ben-Gurion U.
Prof. Raz Jelinek (left) and his student Ravit Malishev. Credit: Dani Machlis/BGU

Researchers from Ben-Gurion University (BGU), together with American and German colleagues, have developed new "molecular tweezers" to combat antibiotic-resistant bacteria. Their recently announced findings were published in Cell Chemical Biology.

For years, have struggled with bacterial infections becoming increasingly resistant to antibiotics. These molecular tweezers may be the key to battling one of greatest public health issues of the 21st century.

"Our discovery prevents infection without building up , and it might even be preferable to develop treatments based on molecular tweezers rather than antibiotics," said BGU Department of Chemistry Prof. Raz Jelinek.

The research team, led by Prof. Jelinek and his Ph.D. student Ravit Malishev, tested their molecular tweezers on the Staphylococcus aureus (Staph) . In the U.S. staph infections have an estimated mortality rate of over 25%, and 40% for drug-resistant strains.

The tweezers target biofilm, a thin layer of fibers that protects the bacteria. By gripping the fibers and destroying the , the tweezers impair the bacteria without directly attacking it, which prevents resistance from occurring.

Prof. Jelinek, who is also BGUs vice president of research and development and a member of the Ilse Katz Institute for Nanoscale Science and Technology, explained, "The tweezers are just like your home tweezers but a million times smaller, and instead of plucking hairs they attack fibers of the bacteria's biofilm." By doing that they break the biofilm, making it more vulnerable to human immune defenses and external substances that are used against bacteria like antibiotics."

"The success of the study indicates an innovative direction of antibiotic treatments against pathogenic bacteria. We found that binding the tweezers to the biofilm disrupts its protective capabilities. Consequently, the bacterial pathogens become, less virulent to the human body, and, more vulnerable to elimination by the immune system. This breakthrough may open up new ways to fight ." Prof. Jelinex hopes that following further testing, a pill containing millions of ingestible could identify biofilms in the body and break them apart.


Explore further

Researchers provide new insights into how antibiotic resistance develops

More information: Ravit Malishev et al, Inhibition of Staphylococcus aureus biofilm-forming functional amyloid by molecular tweezers, Cell Chemical Biology (2021). DOI: 10.1016/j.chembiol.2021.03.013
Journal information: Cell Chemical Biology

Citation: Molecular tweezers that attack antibiotic resistant bacteria (2021, May 10) retrieved 13 June 2021 from https://phys.org/news/2021-05-molecular-tweezers-antibiotic-resistant-bacteria.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
123 shares

Feedback to editors

User comments