Cell Chemical Biology (previously, Chemistry & Biology) publishes reports of novel investigations in all areas at the interface of chemistry and biology. Chemistry & Biology strongly encourages submission of articles in which chemical tools are used to provide unique insight into biological function and mechanism. Studies that illustrate the underlying chemistry of biological processes will also be viewed favorably. Other relevant studies of interest to chemists and biologists will also be considered. In general, to be considered suitable for publication in this journal, investigations that primarily have a genetic, computational, or theoretical focus must contain substantiating experimental data. All articles should not only be of significance to the immediate field but should also be of interest to our diverse readership from the broad chemical-biology community.
Polypharmacology—the ability of a drug to affect more than one protein—should be studied early in the drug discovery pathway, and constantly monitored as the chemical structure is optimized in the design of the clinical ...
Biochemistry
Jun 02, 2021
0
6
Researchers from Ben-Gurion University (BGU), together with American and German colleagues, have developed new "molecular tweezers" to combat antibiotic-resistant bacteria. Their recently announced findings were published ...
Biotechnology
May 10, 2021
0
123
Many anti-cancer drugs block signals in cancer cells that help degenerated cells to multiply uncontrollably and detach from tissue. For example, blocking the signaling protein FAK, a so-called kinase, causes breast cancer ...
Biochemistry
Jan 28, 2021
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16
Scientists have used gene-editing advances to achieve a tenfold increase in the production of super-bug targeting formicamycin antibiotics.
Molecular & Computational biology
Jan 12, 2021
0
648
A new strategy for treating a variety of diseases known as RNA-repeat expansion disorders, which affect millions of people, has shown promise in proof-of-principle tests conducted by scientists at Scripps Research.
Biochemistry
Nov 06, 2020
0
138
Scripps Research chemists Hans Renata, Ph.D., and Alexander Adibekian, Ph.D., have discovered a way to efficiently create a synthetic version of a valuable natural compound called cepafungin I, which has shown promise as ...
Biochemistry
Aug 06, 2020
0
2982
All cells have a lipid membrane that encircles their internal components—forming a protective barrier to control what gets in and what stays out. The proteins embedded in these membranes are essential for life; they help ...
Biochemistry
Dec 19, 2019
0
153
When cells suffer DNA damage, they send out an SOS signal. When the repair crew arrives, the emergency signal is cancelled as it is no longer needed. This two-stage process is an important one in many different diseases, ...
Molecular & Computational biology
Nov 11, 2019
0
12
Selecting the most effective molecules for drug delivery is often a trial-and-error process, but Cornell engineers are providing some precision thanks to a technique that reveals the performance of those molecules inside ...
Biochemistry
Nov 02, 2019
0
123
Human medicines that act on important signal systems in the brain make fish bolder, shows a new study on three-spined sticklebacks by researchers at Linköping University. The results reinforce that the signal substances ...
Plants & Animals
Oct 17, 2019
0
80
