Cell Chemical Biology (previously, Chemistry & Biology) publishes reports of novel investigations in all areas at the interface of chemistry and biology. Chemistry & Biology strongly encourages submission of articles in which chemical tools are used to provide unique insight into biological function and mechanism. Studies that illustrate the underlying chemistry of biological processes will also be viewed favorably. Other relevant studies of interest to chemists and biologists will also be considered. In general, to be considered suitable for publication in this journal, investigations that primarily have a genetic, computational, or theoretical focus must contain substantiating experimental data. All articles should not only be of significance to the immediate field but should also be of interest to our diverse readership from the broad chemical-biology community.

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Malaria hijacks your genes to invade your liver

In the search for new weapons against malaria, most drug development has focused on the parasites that cause the disease. But Duke University researchers are trying a different tack. Instead of targeting the malaria parasite ...

Chemists ID possible addiction-free pain reliever

An estimated 1.7 million Americans suffer from substance abuse disorders related to opioid use for pain relief, according to the National Institute on Drug Abuse. This causes an economic burden of more than $78 billion per ...

How bugs overcome host defenses

Bacterial pathogens must acquire nutrient metals from the host to survive and cause disease. To counter infection, hosts attempt to starve bacteria by hiding metals away in a process called "nutritional immunity." Bacteria ...

A new approach to drugging a difficult cancer target

One of the most common cancer-promoting genes, known as Myc, is also one of the most difficult to target with drugs. Scientists have long tried to develop drugs that block the Myc protein, but so far their efforts have not ...

From mirror-image biology to enhanced therapeutic proteins

Scientists from the German Cancer Research Center (DKFZ) have succeeded in reconstructing biomolecules in their mirror-image form. The researchers' goal is to create a mirror-image artificial protein synthesis system. Their ...

'Undruggable' Parkinson's molecule spills its secrets

UC San Francisco researchers have for the first time developed a strategy for targeting a key molecule implicated in Parkinson's disease, opening up a potential new treatment strategy for the currently incurable movement ...

How a fungus can cripple the immune system

The fungus Aspergillus fumigatus is everywhere, and is extremely dangerous for people with weakened immune systems. It occurs virtually everywhere on Earth, as a dark grey stain on damp walls or in microscopically small spores ...

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