What we've learned about the nucleolus since you left school

May 17, 2018, Cell Press
What we've learned about the nucleolus since you left school
This figure illustrates the tripartite architecture of the nucleolus. Credit: Tiku and Antebi/Trends in Cell Biology

The size of a cell's nucleolus may reveal how long that cell, or even the organism that cell belongs to, will live. Over the past few years, researchers have been piecing together an unexpected link between aging and an organelle typically known as the cell's ribosome factory (or perhaps just a blob in the middle of the nucleus). A May 17th review in the journal Trends in Cell Biology outlines the connections between the nucleolus and age-related pathways—such as those associated with dietary restriction or progeria.

"The nucleolus is perceived as a basic housekeeper: It's responsible for producing ribosomal RNA, which is important for the synthesis of proteins that are essential to the vitality of the cell," says Adam Antebi, director of the Max Planck Institute for Biology of Ageing in Germany, who co-authored the review with postdoctoral fellow Varnesh Tiku. "But our work and other people's work shows that the nucleolus plays many different roles, including lifespan control."

Studies of aging and the nucleolus have been carried out in yeast, worms, fruit flies, mice, as well as early data in humans undergoing and exercise. Worms are particularly useful for aging research because they only live for about a month, so it's possible to tweak their genomes and see what extends or shortens their lifespans. Antebi and others have seen that common pathways related to aging ultimately affect nucleolar size—organisms with enlarged nucleoli have shorter lifespans and those with shrunken nucleoli have longer lifespans.

Many of these longevity pathways converge on a nucleolar regulating gene called NCL-1. Dietary restriction, reduced insulin signaling, and other lifespan-extending interventions increase the activity of NCL-1, reducing nucleolar size and the creation of ribosomes. Worms lacking NCL-1 receive no age-extending benefits from these therapies. Relatedly, people with diseases such as cancer or progeria that accelerated aging have enlarged nucleoli with increased ribosome biogenesis. It is still unclear why a small nucleolus can extend lifespan, but it may be linked to balancing cellular renewal and repair.

This figure illustrates how a variety of factors can lead to decreased nucleolus size and a longer lifespan. Credit: Tiku and Antebi/Trends in Cell Biology

"Within an organism, within different tissues, it's for sure that nucleolar size can vary quite a bit depending on the metabolic activities of the , so for example, in C. elegans, neurons have very small nucleoli whereas they are quite big in skin cells or muscle cells," Antebi says. "It turns out that neurons in C. elegans maintain their structure well into old age, whereas and tend to deteriorate more rapidly in the organism. Thus, even within an organism different tissues have different nucleolar size and it may reflect different rates of aging."

Does this mean that the nucleolus acts as a kind of cellular timer? Not quite. Antebi argues that the organelle—which lacks a membrane and has a unique biochemistry that keeps it separate form the nucleus—is more likely the center for growth control. Too much growth and cells turn cancerous, too little and tissue repair becomes dysfunctional.

"The nucleolus is such an important organelle, it's what has been selected to coordinate all of the different informational processes in the cell that bring protein and RNA together," he says. "What is life but the proper processing of information and responding to environments in ways that are healthful for the cell and organism."

Antebi is interested in learning more about whether the nucleolus is acting on specific age-related pathways or if the organelle has a global effect on organism-level physiology such as immune function or metabolic regulation. The work also raises the possibility of the being a biomarker to monitor the health or longevity of , and a pilot experiment in humans supported this potential. "What if? Perhaps it's a bit of a stretch, but it's an intriguing idea," he says.

Explore further: Nucleolus is a life expectancy predictor

More information: Trends in Cell Biology, Tiku and Antebi: "Nucleolar Function in Lifespan Regulation" DOI: 10.1016/j.tcb.2018.03.007

Related Stories

Nucleolus is a life expectancy predictor

August 31, 2017

Can a cell show its biological age? And is it possible to foresee an animal's lifespan? Scientists from the Max Planck Institute for Biology of Ageing in Cologne discovered a connection between the size of the nucleolus - ...

Protein turnover could be clue to living longer

August 30, 2017

It may seem paradoxical, but studying what goes wrong in rare diseases can provide useful insights into normal health. Researchers probing the premature aging disorder Hutchinson-Gilford progeria have uncovered an errant ...

Secrets of a little-known cancer ally revealed

February 14, 2018

Human cancers often have a little recognized ally— the increased size and number of a cell's organelles called the nucleolus. The nucleolus is where ribosomes, the cellular protein factories, are made. Ribosomes can also ...

Recommended for you

Dragonfly enzymes point to larger evolutionary dynamics

May 24, 2018

Although evolution has left dragonflies virtually unchanged for roughly 300 million years, new research by a UTM biologist reveals that understanding small physiological activities in these insects could reveal a deeper understanding ...

1 comment

Adjust slider to filter visible comments by rank

Display comments: newest first

stambecco
not rated yet May 21, 2018
always a big secret

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.