Undersea life holds promise for killing tuberculosis

July 6, 2017, University of Central Florida
Dr. Rohde and his team are working on unlocking the secrets of sponges and other undersea life that could help combat tuberculosis. Credit: University of Central Florida

A team of researchers at the University of Central Florida has discovered a potential new weapon in the fight against tuberculosis, and it lives in the Little Mermaid's realm.

UCF graduate student Carolina Rodrigues Felix led the study in UCF Assistant Professor Kyle Rohde's lab. Through a partnership with Amy Wright of the Florida Atlantic University's Harbor Branch Oceanographic Institute, the team screened 4,400 chemical extracts derived from extracts of sponges and other to see if they could kill the dormant . Tuberculosis is a highly contagious disease that is one of the top 10 causes of death worldwide.

"To our knowledge this is the largest marine natural product screening on TB and the only one that focused on dormant bacteria," Rohde said.The team identified 26 that were active against replicating tuberculosis bacteria, 19 killed dormant bacteria including seven that were active against both.

"There were some that actually killed the dormant bacteria better than the replicating bacteria, which is a novelty," he said, "as existing drugs are better at killing replicating bacteria."

Findings of the study published in June in the journal Antimicrobial Agents and Chemotherapy, which is published by the American Society of Microbiology. The National Institutes of Health funded the study.

Tuberculosis, an infectious bacterial disease that mainly affects the lungs, is spread from person to person through the air. Globally, there are about 10.5 million new cases and about 1.5 million deaths reported each year.

"One of the biggest problems is the lack of effective treatments," Rohde said. "Tuberculosis is very difficult to treat and in most cases, takes six to nine months of taking at least four drugs daily. And most patients don't stick to their drug regimens for six to nine months because they have undesirable side effects, or they stop taking it when they feel better."

Tuberculosis bacteria have thick cell walls that drugs have difficulty penetrating. The bacteria also express proteins that make it resistant to treatment. And the bacteria can hide within the immune system and become dormant, only to reappear after treatment ends. "Most of the drugs we have only kill bacteria that are trying to replicate," he said, "so we need drugs that can kill those dormant ones."

Scientists have been isolating marine natural compounds from sea sponges and other marine organisms to find treatments for diseases such as cancer and tuberculosis. Rohde said many of these compounds are not in the sponges themselves, but are made from microorganisms such as fungi or bacteria that live on the sponges.

Rohde and his team plan to purify and further isolate the individual compounds in these extracts to identify which ones have antibacterial properties. So far, they have identified five pure compounds with verified antibiotic potential against tuberculosis.

"Once we've identified these compounds, we want to study them to understand how they work," Rohde said. "That way if the compound turns out not to be a great drug for use in humans as is, at least we would have identified a new target for antibiotics. Alternatively, we could work with chemists to modify the to improve its clinical usefulness."

Explore further: New drug lead identified in fight against tuberculosis

Related Stories

Key to tuberculosis cure could lie underwater

March 8, 2013

The search for a cure for deadly infectious diseases has led Brian Murphy deep underwater. Murphy, assistant professor of medicinal chemistry and pharmacognosy at the University of Illinois at Chicago, is collecting actinomycete ...

Tuberculosis drug shows promise against latent bacteria

September 12, 2008

A new study has shown that an investigational drug (R207910, currently in clinical trials against multi-drug resistant tuberculosis strains) is quite effective at killing latent bacteria. This revelation suggests that R207910 ...

Recommended for you

Wearable device measures cortisol in sweat

July 20, 2018

The hormone cortisol rises and falls naturally throughout the day and can spike in response to stress, but current methods for measuring cortisol levels require waiting several days for results from a lab. By the time a person ...

Researchers report two-faced Janus membrane applications

July 20, 2018

Named for the mythical god with two faces, Janus membranes—double-sided membranes that serve as gatekeepers between two substances—have emerged as a material with potential industrial uses. Creating two distinct "faces" ...

Chemists characterize the fatal fungus among us

July 19, 2018

Life-threatening fungal infections affect more than two million people worldwide. Effective antifungal medications are very limited. Until now, one of the major challenges is that the fungal cell wall is poorly understood, ...

Infrared sensor as new method for drug discovery

July 19, 2018

Using an infrared sensor, biophysicists at Ruhr-Universität Bochum (RUB) have succeeded in analysing quickly and easily which active agents affect the structure of proteins and how long that effect lasts. Thus, Prof Dr. ...

0 comments

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more

Click here to reset your password.
Sign in to get notified via email when new comments are made.