New 3-D printing method promises vastly superior medical implants for millions

May 10, 2017 by Steve Orlando
Credit: University of Florida

For the millions of people every year who have or need medical devices implanted, a new advancement in 3D printing technology developed at the University of Florida promises significantly quicker implantation of devices that are stronger, less expensive, more flexible and more comfortable than anything currently available.

In a paper published today in the journal Science Advances, researchers lay out the process they developed for using 3D and soft silicone to manufacture items that millions of patients use: ports for draining bodily fluids, implantable bands, balloons, soft catheters, slings and meshes.

Currently, such devices are molded, which could take days or weeks to create customized parts designed to fit an individual patient. The 3D printing method cuts that time to hours, potentially saving lives. What's more, extremely small and complex devices, such as drainage tubes containing pressure-sensitive valves, simply cannot be molded in one step.

With the UF team's new method, however, they can be printed.

"Our new material provides support for the liquid silicone as it is 3D printing, allowing us create very complex structures and even encapsulated parts out of silicone elastomer," said lead author Christopher O'Bryan, a mechanical and aerospace engineering doctoral student in UF's Herbert Wertheim College of Engineering and lead author on the paper.

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Silicone is 3D printed into the micro-organogel support material. The printing nozzle follows a predefined trajectory, depositing liquid silicone in its wake. The liquid silicone is supported by the micro-organgel material during this printing process.

It also could pave the way for new therapeutic devices that encapsulate and control the release of drugs or small molecules for guiding tissue regeneration or assisting diseased organs such as the pancreas or prostate.

The cost savings could be significant as well.

"The public is more sensitive to the high costs of medical care than ever before. Almost monthly we see major media and public outcry against high , wasteful spending in hospitals, exorbitant pharmaceutical costs," said team member Tommy Angelini, an associate professor of mechanical and aerospace. "Everybody agrees on the need to reduce costs in medicine."

The new method was born out of a project Angelini and his team have been working on for several years: printable organs and tissues. To that end, the team made a significant discovery two years ago when it created a revolutionary way to manufacture soft materials using 3D printing and microscopic hydrogel particles as a medium.

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Water is pumped from one reservoir to another using a 3D printed silicone valve. The silicone valve contains two encapsulated ball valves that allow water to be pumped through the valve by squeezing the lower chamber. The silicone valve demonstrates the ability of our 3D printing method to create multiple encapsulated components in a single part -- something that cannot be done with a traditional 3D printing approach.

The problem was, the previous granular gel materials were water-based, so they were incompatible with oily "inks" like silicone. It was literally a case of trying to mix oil and water.

To solve that problem, the team came up with an oily version of the microgels.

"Once we started printing oily silicone inks into the oily microgel materials, the printed parts held their shapes," Angelini said. "We were able to achieve really excellent 3D printed silicone parts - the best I've seen."

Manufacturing organs and tissues remains a primary goal, but one that likely is many years away from reality.

Liquid silicone is 3-D printed into a micro-organogel support to create a perfusable tube network. Once cured and removed from the support material, water is pumped through the printed structure. Credit: O’Bryan et al. Sci. Adv. 2017;3:e1602800

Not so with the medical implants.

"The reality is that we are probably decades away from the widespread implanting of 3D printed tissues and organs into patients," Angelini said. "By contrast, inanimate are already in widespread use for implantation. Unlike the long wait we have ahead of us for other 3D bioprinting technolgies to be developed, devices can be put into widespread use without technologically limited delay."

Explore further: New 3-D printing method creates shape-shifting objects

More information: Self-assembled micro-organogels for 3D printing silicone structures Science Advances  10 May 2017: Vol. 3, no. 5, e1602800, DOI: 10.1126/sciadv.1602800 , http://advances.sciencemag.org/content/3/5/e1602800

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