Our master circadian clock resides in a small group of about 10'000 neurons in the brain, called the suprachiasmatic nucleus. However, similar clocks are ticking in nearly all cells of the body, as demonstrated by the group ...
Cell & Microbiology
Oct 26, 2012
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German researchers reveal the structure of cellular protein degradation machinery.
Cell & Microbiology
Jan 23, 2012
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The proteasome is the garbage-disposal system of the cell, enzymatically clearing away unwanted proteins. Since this requires the recognition of individual targets within the crowded cellular environment, it is critically ...
Biochemistry
Apr 28, 2011
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An international research team has clarified the regulatory mechanism of the ubiquitin-proteasome system in recognizing and repairing DNA that has been damaged by ultraviolet (UV) light. The investigators at Kobe University ...
Molecular & Computational biology
Dec 8, 2020
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Protein nanomachines made of multiple protein molecules are highly dynamic during their actions on their functional targets, sometime called substrates. Dynamics of these large protein nanomachines of more than megadalton ...
Biochemistry
Feb 26, 2019
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Johns Hopkins researchers have found that the cellular "garbage disposal," known to scientists as proteasomes, may not only be responsible for the removal of cellular waste, but actually work on some of the most important ...
Cell & Microbiology
Jul 10, 2018
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New research from the Korea Institute of Science and Technology, to be published in the Journal of Biological Chemistry on Oct. 13, has found that the proteasome, an essential protein complex that breaks down proteins in ...
Biochemistry
Oct 10, 2017
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Cells have a sophisticated system to control and dispose of defective, superfluous proteins and thus to prevent damage to the body. Dr. Katrin Bagola and Professor Thomas Sommer of the Max Delbrück Center for Molecular Medicine ...
Cell & Microbiology
May 28, 2013
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Researchers at the A*STAR Institute of Medical Biology (IMB) have discovered a critical checkpoint protein that controls when human embryonic stem cells (hESCs) begin to differentiate.
Cell & Microbiology
Feb 27, 2013
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Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively kills cells ...
Biochemistry
Feb 16, 2012
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