How cells dispose of their waste
German researchers reveal the structure of cellular protein degradation machinery.
Cell & Microbiology
Jan 23, 2012
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0
News tagged with proteasome
Related topics:
protein
Chemists build natural anti-cancer compound with efficient new process
Scripps Research chemists Hans Renata, Ph.D., and Alexander Adibekian, Ph.D., have discovered a way to efficiently create a synthetic version of a valuable natural compound called cepafungin I, which has shown promise as ...
Biochemistry
Aug 6, 2020
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2982
Detailed structure of cell's garbage disposal unit reveals surprise in how it is targeted by cancer drugs
Cancer cells are more dependent on a cellular garbage disposal unit—the proteasome—than healthy cells, and cancer therapies take advantage of this dependency. Scientists at EMBL and MPI determined the proteasome's 3D ...
Biochemistry
Aug 4, 2016
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872
Making a molecular micromap: Imaging the yeast 26S proteasome at near-atomic resolution
(Phys.org)—Biological systems are characterized by a form of molecular recycling – and proteins do not escape this fate. In particular, unneeded or damaged proteins biochemically marked for destruction undergo controlled ...
New insight into the evolution of complex life on Earth
A novel connection between primordial organisms and complex life has been discovered, as new evidence sheds light on the evolutionary origins of the cell division process that is fundamental to complex life on Earth.
Evolution
Aug 6, 2020
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161
Team solves structure of 'flipping' cellular machine, pointing to possible Alzheimer's and cancer therapies
Meet a microscopic gymnast. A new study led by scientists at The Scripps Research Institute (TSRI) and the University of California (UC), Berkeley shows how a crucial molecular enzyme starts in a tucked-in somersault position ...
Cell & Microbiology
Jan 25, 2016
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63
How to kill a protein
For decades scientists have been looking closely at how our cells make proteins. But the inverse is equally important: how cells kill them.
Cell & Microbiology
Apr 24, 2015
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23
Protein-devouring enzyme complex uses two different mechanisms to determine which targets to destroy
The proteasome is the garbage-disposal system of the cell, enzymatically clearing away unwanted proteins. Since this requires the recognition of individual targets within the crowded cellular environment, it is critically ...
Biochemistry
Apr 28, 2011
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0
Immunoproteasome crystal structure determined
Like a shredder, the immunoproteasome cuts down proteins into peptides that are subsequently presented on the cellular surface. The immune system can distinguish between self and nonself peptides and selectively kills cells ...
Biochemistry
Feb 16, 2012
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0
Proteasome phase separation for destruction
The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins. As the maintenance of protein homeostasis is essential to human health, malfunctions ...
Molecular & Computational biology
Apr 27, 2020
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