Light-carved 'nano-volcanoes' hold promise for drug delivery

Jun 13, 2013 by Matt Shipman
Researchers from NC State University are able to carve nanoscale "volcanoes" by scattering light through a polymer "crystal ball" onto a photo-reactive thin film. The structures hold promise for new drug-delivery technologies. Credit: Chih-Hao Chang, North Carolina State University

(Phys.org) —Researchers from North Carolina State University have developed a method for creating "nano-volcanoes" by shining various colors of light through a nanoscale "crystal ball" made of a synthetic polymer. These nano-volcanoes can store precise amounts of other materials and hold promise for new drug-delivery technologies.

The researchers create the nano-volcanoes by placing spherical, transparent polymer nanoparticles directly onto the of a thin film. They then shine through the transparent sphere, which scatters the light and creates a pattern on the thin film. The thin film is made of a photoreactive material that undergoes a chemical change wherever it has been struck by the light. The researchers then submerge the thin film in a that washes away the parts of the film that were exposed to light. The material that remains is shaped like a nanoscale .

"We can control the pattern of light by changing the diameter of the nanoparticle spheres, or by changing the wavelength – or color – of the light that we shine through the spheres," says Xu Zhang, a doctoral student in mechanical and aerospace engineering at NC State and lead author of a paper describing the work. "That means we can control the shape and geometry of these structures, such as how big the cavity of the nano-volcano will be."

The researchers developed a highly accurate that predicts the shape and dimensions of the nano-volcanoes based on the diameter of the nanoscale sphere and the .

Because these structures have precisely measured hollow cores, and precisely measured openings at the "mouth" of the nano-volcanoes, they are good candidates for drug-delivery mechanisms. The size of the core would allow users to control the amount of the drug a nano-volcano would store, while the size of the opening at the top of the nano-volcano could be used to regulate the drug's release.

NC State University researchers have created nanoscale "volcanoes" that can then be packed with precise amounts of other materials, including drugs. The approach holds promise for drug-delivery systems. Credit: Chih-Hao Chang, North Carolina State University

"The materials used in this process are relatively inexpensive, and the process can be easily scaled up," says Dr. Chih-Hao Chang, an assistant professor of mechanical and at NC State and co-author of the paper. "In addition, we can produce the nano-volcanoes in a uniformly patterned array, which may also be useful for controlling drug delivery."

Chang's team is now working to improve its understanding of the release rate from the nano-volcanoes, such as how quickly nanoparticles of different sizes will "escape" from nano-volcanoes with different-sized mouths. "That's essential information for drug-delivery applications," Chang says.

"It's exciting to take our understanding of how light scatters by particles and apply it to nanolithography in order to come up with something that could actually help people."

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More information: The paper, "Three-Dimensional Nanolithography Using Light Scattering from Colloidal Particles," was published online June 12 in ACS Nano. DOI: 10.1021/nn402637a http://pubs.acs.org/doi/abs/10.1021/nn402637a

Abstract
The interaction between light and colloidal elements can result in a wealth of interesting near-field optical patterns. By examining the optical and colloidal properties, the intensity distribution can be tailored and harnessed for three-dimensional nanolithography. Here, we examine the use of light scattering from colloidal particles to fabricate complex hollow nanostructures. In this approach, a single colloidal sphere is illuminated to create a scattering pattern, which is captured by photoresist in close proximity. No external optical elements are required, and the colloidal elements alone provide the modulation of the optical intensity pattern. The fabricated nanostructures can be designed to have multiple shells, confined volumes, and single top openings, resembling "nano-volcanoes." The geometry of such structures is dependent on the scattered light distribution, and can be accurately modeled by examining the light-particle interaction. The hollow nanostructures can be used to trap nanomaterial, and we demonstrate their ability to trap 50 nm silica nanoparticles. These well-defined surface hollow structures can be further functionalized for applications in controlled drug delivery and bio-trapping. Colloidal elements with different geometries and material compositions can also be incorporated to examine other light-colloid interactions.

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