Transcription factors regulate gene expression by binding specific sequences on DNA, which is an essential step to producing messenger RNAs from protein-coding genes. Denes Hnisz's lab, in collaboration with Martin Vingron's ...
Cell & Microbiology
Jul 5, 2024
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Rubus rosaefolius, a red raspberry, is valued for its nutritional and medicinal properties, containing bioactive compounds like anthocyanins. Despite its potential, there is limited genomic information available.
Molecular & Computational biology
Jun 17, 2024
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Drought stress poses a significant challenge to plant survival, affecting growth and productivity. Transcription factors, particularly NAC proteins, play vital roles in plant responses to abiotic stress.
Molecular & Computational biology
Jun 17, 2024
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A recent study has pinpointed a novel bHLH gene, MabHLH28, as a key regulator of banana fruit ripening. This gene significantly influences the softening process by upregulating the expression of softening-related genes, either ...
Molecular & Computational biology
Jun 13, 2024
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Recent research has uncovered the genetic mechanisms behind sea lavender's (Limonium bicolor) salt tolerance by studying basic helix–loop–helix (bHLH) transcription factors. Identifying 187 bHLH genes, the study highlights ...
Molecular & Computational biology
Jun 5, 2024
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In a study published in Nature Communications, researchers have deciphered the molecular mechanism that regulates the rhythmic movements of stomata throughout the day.
Plants & Animals
May 29, 2024
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A study from the University of Adelaide has discovered molecular pathways regulated by a gene traditionally used to control wheat-flowering behavior could be altered to achieve greater yields. The research was published in ...
Molecular & Computational biology
May 23, 2024
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Wheat plays a critical role in global food security, but water scarcity in arid and semi-arid regions hinders its efficient production, suggesting significant opportunities for water saving. Therefore, understanding the genes ...
Molecular & Computational biology
May 17, 2024
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2
A review delves into the significance of biomolecular condensation in cellular processes, the impact of aberrant phase separation on diseases such as neurodegenerative diseases, cancers, and infectious diseases, and the potential ...
Cell & Microbiology
May 16, 2024
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Researchers at the Francis Crick Institute and King's College London have discovered that how soft or rigid proteins are in certain regions can dictate how fast or slow they enter the nucleus.
Cell & Microbiology
May 13, 2024
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In the field of molecular biology, a transcription factor (sometimes called a sequence-specific DNA binding factor) is a protein that binds to specific DNA sequences and thereby controls the transfer (or transcription) of genetic information from DNA to mRNA. Transcription factors perform this function alone or with other proteins in a complex, by promoting (as an activator), or blocking (as a repressor) the recruitment of RNA polymerase (the enzyme which performs the transcription of genetic information from DNA to RNA) to specific genes.
A defining feature of transcription factors is that they contain one or more DNA binding domains (DBDs) which attach to specific sequences of DNA adjacent to the genes that they regulate. Additional proteins such as coactivators, chromatin remodelers, histone acetylases, deacetylases, kinases, and methylases, while also playing crucial roles in gene regulation, lack DNA binding domains, and therefore are not classified as transcription factors.
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