Boosting virtual screening with machine learning allowed for a 10-fold time reduction in the processing of 1.56 billion drug-like molecules. Researchers from the University of Eastern Finland teamed up with industry and supercomputers ...
Analytical Chemistry
Sep 22, 2023
0
18
Ion channels are attractive drug targets due to their importance in health and disease, but finding ways to target a specific ion channel selectively is a major challenge. Now, researchers at Weill Cornell Medicine and RMIT ...
Biochemistry
Aug 31, 2023
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8
Cocaine use continues to be a public health problem, yet despite concerted efforts, no drugs have been approved to resolve cocaine addiction. Research suggests that the attention-deficit/hyperactivity disorder drug methylphenidate ...
Biochemistry
Aug 30, 2023
0
48
A team of investigators in the laboratory of Ali Shilatifard, Ph.D., the Robert Francis Furchgott Professor and chair of Biochemistry and Molecular Genetics, have discovered a novel protein region responsible for regulating ...
Cell & Microbiology
Jul 14, 2023
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25
In drug delivery, the therapeutic behavior of the nanocarriers is limited by the "foreign" character of their surface. Despite the wide range of sophisticated coatings available, immune cells often identify these synthetic ...
Bio & Medicine
Jul 13, 2023
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31
A team of researchers from the Universities of Amsterdam and Zurich together with the Swiss company Allocyte Pharmaceuticals have for the first time been able to discover allosteric sites in a type of cell surface receptor ...
Biochemistry
Jun 28, 2023
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1
A new type of drug could provide a way to treat multidrug-resistant bacteria, according to a study published in Nature Communications. Instead of targeting the bacteria directly, the drug blocks key toxins involved in the ...
Cell & Microbiology
Apr 18, 2023
1
67
There is a need for new drugs. For example, many of the antibiotics that we have been using for a long time are becoming less effective. Chemists and pharmaceutical scientists are frantically searching for new active substances, ...
Biochemistry
Apr 13, 2023
0
38
CycPeptMPDB, a novel database created by Tokyo Tech researchers, focuses on the membrane permeability of cyclic peptides and could accelerate the development of drugs based on these promising compounds. This database was ...
Biochemistry
Apr 5, 2023
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36
A team of chemists at MIT has found that using peptides instead of DNA fragments to tag small molecules can speed up the drug discovery process. Their research is published in the journal Science.
