Researchers have discovered ways to convert inhibitor-style targeted cancer drugs into small molecules known as degraders, which help destroy cancer-promoting proteins in cells.
Biochemistry
Apr 11, 2024
0
34
A recent breakthrough sheds light on how the malaria parasite, Plasmodium falciparum, invades human red blood cells. The study, led by the Swiss Tropical and Public Health Institute (Swiss TPH) and Griffith University's Institute ...
Cell & Microbiology
Apr 3, 2024
0
0
Helicases are enzymes that unwind DNA and RNA. They're central to cellular life, implicated in a number of cancers and infections—and, alas, extraordinarily difficult to target with drugs.
Biochemistry
Mar 7, 2024
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31
An online platform powered by deep learning can predict the makeup of new psychoactive substances to help law enforcement in the fight against dangerous drugs.
Analytical Chemistry
Feb 29, 2024
2
13
Aptamers, nucleic acids capable of selectively binding to viruses, proteins, ions, small molecules, and various other targets, are garnering attention in drug development as potential antibody substitutes for their thermal ...
Cell & Microbiology
Jan 2, 2024
0
66
Just like a doctor adjusts the dose of a medication to the patient's needs, the expression of therapeutic genes, those modified in a person to treat or cure a disease via gene therapy, also needs to be maintained within a ...
Biotechnology
Jan 2, 2024
0
155
The capacity to regulate the biodistribution of therapeutics is a highly desired feature that can limit the side effects of many drugs. In a new study in Scientific Reports, Noah Joseph, and a team of biotechnology and nanoscience ...
A combination of machine learning and lab experiments has given researchers a peek into the different languages bacteria use to communicate. Understanding how bacteria communicate—and when they can't—has implications ...
Biotechnology
Nov 24, 2023
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37
Most drugs are small molecules that bind firmly to a specific target—some molecule in human cells that is involved in a disease—in order to work. For example, a cancer drug's target might be a molecule that is abundant ...
Biochemistry
Sep 29, 2023
0
59
Boosting virtual screening with machine learning allowed for a 10-fold time reduction in the processing of 1.56 billion drug-like molecules. Researchers from the University of Eastern Finland teamed up with industry and supercomputers ...
Analytical Chemistry
Sep 22, 2023
0
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