A research project that began 20 years ago with an interest in how lithium treats mood disorders has yielded insights into the progression of blood cancers such as leukemia. The research, which centers on a protein called ...
Biochemistry
Oct 31, 2017
0
25
It's well known that when the DNA in a cell is damaged, the cell responds by activating specific genes that help defend the integrity of its genome. But less well studied is the fact that the cell actually shuts down the ...
Cell & Microbiology
Feb 17, 2017
0
14
If you imagine a cell as a house, protein production can be a fairly relatable engineering feat. A master blueprint (DNA) holds all the information about what goes where. If you just want to build a door (protein), you only ...
Cell & Microbiology
Feb 25, 2016
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9
Like a film director cutting out extraneous footage to create a blockbuster, the cellular machine called the spliceosome snips out unwanted stretches of genetic material and joins the remaining pieces to fashion a template ...
Cell & Microbiology
Mar 21, 2010
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0
UCLA researchers have solved the high-resolution structure of a massive cellular machine, the spliceosome, filling the last major gap in our understanding of the RNA splicing process that was previously unclear.
Biochemistry
Nov 17, 2017
0
8
Single-cell RNA sequencing (scRNA-seq) has revolutionized the ability to characterize cell types and their gene expression programs in organisms and tissues. Although great improvements in cellular throughput have been made, ...
Biotechnology
May 7, 2020
0
37
Embryonic stem cells (ESCs) retain their ability to self-renew indefinitely thanks to a number of proteins known as pluripotency factors. These factors must be modified at the RNA level before they are turned into proteins ...
Cell & Microbiology
Jan 29, 2014
0
0
A new way of mapping the "transcriptome"—the collection of RNA read-outs that are expressed by a cell's active genes—has been devised by researchers from the Perelman School of Medicine at the University of Pennsylvania. ...
Cell & Microbiology
Feb 9, 2016
1
17
Flowers rely on a newly identified protein to develop properly with all of their organs, according to the research team who made the discovery. The team, led by Penn State biologists, identified the protein in the model plant ...
Plants & Animals
Feb 5, 2024
0
68
An international team of researchers has discovered unexpected functions of small nucleolar RNAs (snoRNAs) that explains the cause of some diseases. The research, led by Prof. Stefan Stamm from the University of Kentucky ...
Cell & Microbiology
Jun 6, 2016
0
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