Researchers discover that protein switches functions to regulate DNA replication
One protein. One mechanism of action. Two biologically opposite effects.
Biotechnology
Jul 23, 2021
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News tagged with replication fork
Study reveals new role for RNA interference during chromosomal replication
At the same time that a cell's DNA gets duplicated, a third of it gets super-compacted into repetitive clumps called heterochromatin. This dense packing serves to repress or "silence" the DNA sequences within -- which could ...
Cell & Microbiology
Oct 16, 2011
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Unusual mechanism of DNA synthesis could explain genetic mutations
Researchers have discovered the details of how cells repair breaks in both strands of DNA, a potentially devastating kind of DNA damage.
Biotechnology
Sep 11, 2013
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High fidelity: Researcher finds keys to genome integrity
Maintaining the stability and the correct sequence of our genetic information is vital to the accurate transmission of our genetic code. However, in the course of replicating, our DNA frequently runs into roadblocks, arising ...
Cell & Microbiology
Apr 14, 2015
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Handle with care: Telomeres resemble DNA fragile sites
(PhysOrg.com) -- Telomeres, the repetitive sequences of DNA at the ends of linear chromosomes, have an important function: They protect vulnerable chromosome ends from molecular attack. Researchers at Rockefeller University ...
Cell & Microbiology
Jul 10, 2009
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Malignant cells adopt a different pathway for genome duplication
Genomes must be replicated in two copies during cell division. This process occurs at structures called 'replication forks', which are equipped with enzymes and move along the separated DNA strands. In tumour cells, the replication ...
Cell & Microbiology
Dec 5, 2013
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Tumors elude anti-cancer drugs through 'fork reversal' repair
In research recently published in Nature Structural & Molecular Biology, Alessandro Vindigni, Ph.D., associate professor of biochemistry and molecular biology at Saint Louis University, discovered how cancer cells respond ...
Cell & Microbiology
Aug 6, 2013
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Unveiling the mechanism protecting replicated DNA from degradation
Researchers from Tokyo Metropolitan University and the FIRC Institute of Molecular Oncology (IFOM) in Italy have succeeded in depleting AND-1, a key protein for DNA replication, by using a recently developed conditional protein ...
Cell & Microbiology
Oct 1, 2018
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Detangling DNA replication
DNA is a lengthy molecule—approximately 1,000-fold longer than the cell in which it resides—so it can't be jammed in haphazardly. Rather, it must be neatly organized so proteins involved in critical processes can access ...
Cell & Microbiology
Sep 18, 2018
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Rockefeller scientists first to reconstitute the DNA 'replication fork'
When a cell divides, it must first make a copy of its DNA, a fundamental step in the life cycle of cells that occurs billions of times a day in the human body. While scientists have had an idea of the molecular tools that ...
Cell & Microbiology
Jul 9, 2014
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