New research could significantly accelerate drug discovery

Many drugs work by inhibiting protein enzymes associated with a particular disease. Unfortunately, the same drugs can inhibit protein enzymes unrelated to the disease, resulting in harmful side effects. One potential solution ...

Enzyme from briny deep resurrected in the lab

Mysterious microbes that thrive in hot and super-salty brine lakes at the bottom of the Red Sea could yield a treasure trove of new enzymes for industrial applications—if only scientists had access to their biological bounty.

Researchers report first 3-D structure of DHHC enzymes

The first three-dimensional structure of DHHC proteins—enzymes involved in many cellular processes, including cancer—explains how they function and may offer a blueprint for designing therapeutic drugs. Researchers have ...

Tracking protein disposal could lead to improved therapies

Northwestern Medicine investigators developed a technique to catalog how cells dispose of unnecessary proteins, a process that has implications for cancer and autism-spectrum diseases, according to findings published in Nature ...

Self-defense for plants

When you see brown spots on otherwise healthy green leaves, you may be witnessing a plant's immune response as it tries to keep a bacterial infection from spreading. Some plants are more resistant to such infections than ...

An unusual form of antibiotic resistance in pandemic cholera

Cholera is a devastating disease for millions worldwide, primarily in developing countries, and the dominant type of cholera today is naturally resistant to one type of antibiotic usually used as a treatment of last resort.

Quality control is vital for the energy production of cells

Mitochondria generate most of the energy cells need through a respiratory chain for which they must produce their own proteins. The research group of Associate Professor Henna Tyynismaa, University of Helsinki, Finland, has ...

Bacteria development marks new era in cellular design

Scientists at the universities of Kent and Bristol have built a miniature scaffold inside bacteria that can be used to bolster cellular productivity, with implications for the next generation of biofuel production.

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