Subtle changes in chemical structure can affect drug toxicity
NUS pharmaceutical scientists have discovered the mechanisms involved when small chemical modifications to certain pharmaceutical drugs may cause harm instead of improving treatment.
NUS pharmaceutical scientists have discovered the mechanisms involved when small chemical modifications to certain pharmaceutical drugs may cause harm instead of improving treatment.
Biochemistry
Jan 15, 2018
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16
In a new study, MIT researchers have developed nanoparticles that can deliver the CRISPR genome-editing system and specifically modify genes in mice. The team used nanoparticles to carry the CRISPR components, eliminating ...
Biotechnology
Nov 13, 2017
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899
Portuguese researchers at Instituto de Medicina Molecular (iMM) Lisboa have identified a defense mechanism by which the Plasmodium parasite can survive inside its host's liver cells, a crucial stage in which it acquires the ...
Cell & Microbiology
Nov 7, 2017
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77
When it's raining on the roads, slopes of road dust and contaminants drain into the trenches. What impact does it have on wildlife living by the road?
Environment
Oct 16, 2017
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3
A little-studied gene may explain how some liver cancer cells obtain the nutrition they need to proliferate, according to new research from the University of Maryland. The results of this research will be published as an ...
Biochemistry
Aug 10, 2017
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4
Artificially constructed human tissues and organs have been developed with a number of different purposes in mind, from advanced robotics and novel materials to drug screening. The precision demanded by drug screening applications ...
Analytical Chemistry
Aug 3, 2017
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2
A new study from Harvard T.H. Chan School of Public Health and Howard Hughes Medical Institute sheds light on how a key fat-producing enzyme helps protect cells from a toxic form of fat.
Cell & Microbiology
Aug 1, 2017
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111
A research team led by scientists at UC San Francisco has developed a computational method to systematically probe massive amounts of open-access data to discover new ways to use drugs, including some that have already been ...
Computer Sciences
Jul 12, 2017
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17
Many potent anti-cancer drugs have major drawbacks—they fail to mix with water, which means they will have a limited solubility in blood, and they lack selectivity to cancer cells.
Materials Science
Jun 28, 2017
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2
Various cell therapies involve injecting a specific cell type into a patient. These include, for example, bone marrow transplants and some types of immunotherapy that use T-cells (a white blood cell involved in immunity) ...
Cell & Microbiology
May 1, 2017
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4