Related topics: cells · liver · hepatitis c · liver disease · stem cells

3-D culturing hepatocytes on a liver-on-a-chip device

Liver-on-a-chip cell culture devices are attractive biomimetic models in drug discovery, toxicology and tissue engineering research. To maintain specific liver cell functions on a chip in the lab, adequate cell types and ...

CRISPR-carrying nanoparticles edit the genome

In a new study, MIT researchers have developed nanoparticles that can deliver the CRISPR genome-editing system and specifically modify genes in mice. The team used nanoparticles to carry the CRISPR components, eliminating ...

Human stem cells converted to functional lung cells

For the first time, scientists have succeeded in transforming human stem cells into functional lung and airway cells. The advance, reported by Columbia University Medical Center (CUMC) researchers, has significant potential ...

Scientists discover 'bulkheads' between liver cells

Researchers from Skoltech and their colleagues from Germany and the U.S. have discovered structures responsible for the shape of bile canaliculi, a network of canals in the liver. Published in the Journal of Cell Biology, ...

High-throughput metabolic profiling of single cells

Scientists from the European Molecular Biology Laboratory (EMBL) and the German Cancer Research Center (DKFZ) have presented a new method for generating metabolic profiles of individual cells. The method, which combines fluorescence ...

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Hepatocyte

Hepatocytes make up 70-80% of the cytoplasmic mass of the liver. These cells are involved in protein synthesis, protein storage and transformation of carbohydrates, synthesis of cholesterol, bile salts and phospholipids, and detoxification, modification and excretion of exogenous and endogenous substances. The hepatocyte also initiates the formation and secretion of bile.

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