Related topics: cells · liver · hepatitis c · liver disease · stem cells

Malaria hijacks your genes to invade your liver

In the search for new weapons against malaria, most drug development has focused on the parasites that cause the disease. But Duke University researchers are trying a different tack. Instead of targeting the malaria parasite ...

Early in vitro testing for adverse effects on embryos

ETH researchers have combined embryonic cells and liver cells in a new cell culture test. This combination lets them detect adverse effects that new medications may have on embryos early on in the drug development process.

New progress in developing an animal model of hepatitis C

Small differences in a liver cell protein have significant impacts on hepatitis C virus replication in mice and humans, findings that could facilitate the development of a mouse model of the infection. The report, led by ...

3-D culturing hepatocytes on a liver-on-a-chip device

Liver-on-a-chip cell culture devices are attractive biomimetic models in drug discovery, toxicology and tissue engineering research. To maintain specific liver cell functions on a chip in the lab, adequate cell types and ...

A molecular look at nascent HDL formation

Oil and water don't mix. But our aqueous blood is full of different types of hydrophobic lipids—including cholesterol. In order to travel via the bloodstream, those lipids need to hitch a ride on an amphipathic carrier. ...

Damaged liver cells undergo reprogramming to regenerate

In Greek mythology, Zeus punishes the trickster Prometheus by chaining him to a rock and sending an eagle to eat a portion of his liver every day, in perpetuity. It was the right organ to target – the liver has the ability ...

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Hepatocyte

Hepatocytes make up 70-80% of the cytoplasmic mass of the liver. These cells are involved in protein synthesis, protein storage and transformation of carbohydrates, synthesis of cholesterol, bile salts and phospholipids, and detoxification, modification and excretion of exogenous and endogenous substances. The hepatocyte also initiates the formation and secretion of bile.

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