Researchers at Fox Chase Cancer Center have demonstrated that it might be possible to treat genetic diseases, including some forms of cancer, by "rescuing" the misshapen, useless proteins produced by some mutant genes.
Feb 11, 2009
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Following a single protein inside the cavity of a GroEL chaperone for the first time, researchers at AMOLF led by professor Sander Tans discovered how protein folding can be accelerated. Amino acid chains are pulled inside ...
Biotechnology
Mar 8, 2022
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91
Proteins are the workhorses of our cells, carrying out essential tasks to keep our cells – and our bodies – functioning properly. But proteins can only do their jobs if they fold into the right shape.
Cell & Microbiology
Nov 28, 2018
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The genetic material of our cells—DNA—exists in a high-order structure called chromatin. Chromatin consists of DNA wrapped around histone proteins and efficiently packs DNA into a small volume. Moreover, using a spool ...
Molecular & Computational biology
Jan 23, 2020
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Researchers at the University of Freiburg report a mechanism inside cells that transports proteins to the mitochondria. Their research has now been published in the science journal Cell Reports.
Cell & Microbiology
Nov 26, 2018
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Chaperones are specialized proteins in the cell that help other proteins to reach their functional 3-D shapes, which correspond to the states preferred at thermodynamic equilibrium. But a new study by EPFL, UNIL and INSERM ...
Biochemistry
Mar 5, 2018
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In the cell nucleus, histones play a crucial role packaging DNA into chromatin. Histones are however very sticky to both DNA and RNA, so to ensure they are transported to the cell nucleus after synthesis and bind to the right ...
Cell & Microbiology
Apr 14, 2021
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Kansas State University scientists helped discover new details about an intricate process in cells. Their finding may advance treatments for cancer and neurological diseases.
Cell & Microbiology
May 6, 2013
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Temperature and dissolved oxygen (DO) can affect a series of physiological and biochemical responses and drive the expression of regulatory genes. When water temperature increases, the solubility of oxygen decreases, leading ...
Plants & Animals
Jan 21, 2022
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18
X-ray and electron microscopy techniques help unfold the story of protein chaperones.
Biochemistry
Feb 25, 2019
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