Proteins tend to fold wrongly and become defective when exposed to stressors such as heat, oxidation, and pH changes. Accumulation of abnormal proteins contributes to neurodegenerative diseases like Alzheimer's.
Cell & Microbiology
May 11, 2023
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16
UNC scientists who study how cells repair damage from environmental factors like sunlight and cigarette smoke have discovered how a "chaperone" enzyme plays a key role in cells' ability to tolerate the DNA damage that leads ...
Cell & Microbiology
Jan 18, 2011
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0
An ancient chemical, present for billions of years, appears to have helped proteins function properly since time immemorial.
Cell & Microbiology
Feb 20, 2014
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0
Buried deep within the dazzlingly intricate machinery of the human cell could lie a key to treating a range of deadly cancers, according to a team of scientists at Florida State University.
Cell & Microbiology
Feb 26, 2019
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96
Published in the Molecular Cell journal on July 19, a research study out of the Hatters Laboratory showed inappropriate protein aggregation is linked to poor outcomes for cell health and survival—especially in neurons in ...
Cell & Microbiology
Jul 19, 2022
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16
A study led by UT Southwestern has identified a mechanism that controls the activity of proteins known as chaperones, which guide proteins to fold into the right shapes. The findings, published online today in Nature Communications, ...
Molecular & Computational biology
Feb 11, 2021
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174
Most people don't think much about zinc. But all living things need zinc for survival. This trace element helps many proteins fold into the right shapes to do their jobs. And in proteins known as enzymes, zinc helps catalyze ...
Biochemistry
May 17, 2022
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191
Just like teenagers at a prom, proteins are tended by chaperones whose job it is to prevent unwanted interactions among immature clients. And at the molecular level, just as at the high school gym level, it's a job that usually ...
Cell & Microbiology
Dec 28, 2009
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0
Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray crystallography, they ...
Biochemistry
Mar 1, 2012
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0
How cells respond in the face of stress is a critical component of maintaining homeostasis and preventing disease, but its mechanisms are poorly understood. New research out of the University of Chicago has fit together another ...
Cell & Microbiology
Jan 18, 2021
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