Defining the centromere

The division of cells is a highly-regulated and complex process which requires the organised collaboration of a multitude of different cellular components. Although the basic principles are known, many components and their ...

Trees remember heatwaves

An Aussie eucalypt can 'remember' past exposure to extreme heat, which makes the tree and its offspring better able to cope with future heatwaves, according to new research from Macquarie University.

Maximum precision in protein synthesis

Researchers from the Center for Molecular Biology of Heidelberg University (ZMBH) and the German Cancer Research Center (DKFZ) have investigated the mode of action of a molecular chaperone vital to protein synthesis. Together ...

Researchers deepen understanding of cellular stress responses

Chronic stress caused by changing temperatures, Alzheimer's disease or other diseases and forces is an unavoidable part of life. At the cellular level, the "first responders" to stress are known as molecular chaperones. Yet ...

Cellular stress defense

Small heat-shock proteins (sHSPs) are molecular chaperones that bind to unfolded proteins to prevent protein aggregation and defend against cellular stress. Mutations in human sHSPs are associated with inherited diseases ...

Molecular assembly line brings muscles into shape

Scientists at the Research Institute of Molecular Pathology (IMP) in Vienna, Austria and at the University of Cologne, Germany have discovered the molecular basis underlying the patterned folding and assembly of muscle proteins. ...

A look at the molecular quality assurance within cells

Proteins fulfill vital functions in our body. They transport substances, combat pathogens, and function as catalysts. In order for these processes to function reliably, proteins must adopt a defined three-dimensional structure. ...

Shaping proteins to understand chaperone-related diseases

Chaperones are a set of proteins that are specialised to assist proteins in the human body. They help proteins to fold to the right shape and protect them from adapting wrong shapes. The research group of Alireza Mashaghi, ...

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