Study reveals gut cells' role in marine worm regeneration

The sea worm Platynereis dumerilii is only a few centimeters long, but has a remarkable ability: In just a few days, it can regenerate entire parts of its body after an injury or amputation. By focusing more specifically on the mechanisms at play in the regeneration of this worm's tail, a research team led by a CNRS scientist has observed that gut cells play a role in the regeneration of the intestine as well as other tissues such as muscle and epidermis.

Even more surprising, the team found that this ability of gut cells to regenerate other tissue varies according to their location: The closer they are to the posterior end of the worm, the greater the variety of cell types they can rebuild. This study appears in the journal Development.

Scientists carried out these observations by monitoring the outcome of gut cells and proliferative cells that form close to the amputated end of the worm. This was tracked using different markers, in particular by fluorescent beads ingested by the worms. Annelids, (segmented worms), which have only been studied in the last 20 years, are an ideal model for the study of regeneration, a process that is widespread in animals but still mysterious for scientists.

The research team will continue this work to determine whether cell types, other than gut cells, can play a role in regenerating a variety of cell types.