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Missing gene in mouse sperm could explain infertility

Missing gene could explain infertility
It was found that male mice with no ability to produce the MC2 protein were unable to form the connection between the tail and the head of the sperm and the mice became infertile. The microscope images clearly show the difference in the sperm. Credit: Kexin Zhang

Mice lacking a certain gene are unable to produce offspring because their sperm lack the connection between the tail and the head. A new thesis from the University of Gothenburg indicates a probable cause of male infertility.

Researchers at the University of Gothenburg have identified a new protein, which they have dubbed "MC2," that plays a crucial part in the formation of swimmable sperm in mice. This protein is needed to create a functional connection between the head and the tail of the sperm.

"The connection is located in the 'neck' of the sperm head and facilitates coordinated movement and function as the sperm swims towards the egg. Certainly, the tail and head will each be created perfectly without such a connection—but to no avail, as they will be unable to reach their target," says Kexin Zhang, a doctoral student at the Department of Chemistry and Molecular Biology at the University of Gothenburg.

Gene of no importance for females

Experiments on mice indicated to Kexin Zhang and her research colleagues that production of the MC2 protein was controlled by a specific gene in the genome. When the gene was removed using genetic scissors, the researchers saw that the stopped producing the protein and became completely infertile. It is already known that are responsible for 15 to 30% of infertility in men. The gene is not on the sex chromosome and had no impact on the females' ability to produce offspring.

"My research helped to enhance understanding of the causes of infertility due to the absence of the of the sperm, which is known as acephalic spermatozoa syndrome. The underlying cause of this diagnosis has been unknown until now," says Kexin Zhang.

The discovery of the MC2 provides new insights into the molecular structure of sperm cells that then develop into spermatozoa. Researchers will be able to study these insights further.

"It is estimated that some 15 percent of all have problems with having children. The man is responsible for the problems in about half of these cases. I hope our research will eventually lead to new diagnostic methods and new treatments for male infertility. It may also be possible to create a male contraceptive by switching off this gene," says Kexin Zhang.

More information: Thesis: Preserving Genetic Integrity in Reproduction: Insights from Telomere Protection and Sperm Head-Tail Junctions.

Citation: Missing gene in mouse sperm could explain infertility (2024, January 18) retrieved 21 April 2024 from
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