Understanding astronaut muscle wasting at the molecular level

astronaut
Credit: CC0 Public Domain

Researchers from the University of Tsukuba have sent mice into space to explore effects of spaceflight and reduced gravity on muscle atrophy, or wasting, at the molecular level.

Gravity is a constant force on Earth, which all living creatures have evolved to rely on and adapt to. Space exploration has brought about many scientific and , yet manned spaceflights come at a cost to astronauts, including reduced and strength.

Conventional studies investigating the effects of reduced gravity on muscle mass and function have used a ground control group that is not directly comparable to the space experimental group. Researchers from the University of Tsukuba set out to explore the effects of gravity in mice subjected to the same housing conditions, including those experienced during launch and landing. "In humans, spaceflight causes muscle atrophy and can lead to serious medical problems after return to Earth," says senior author Professor Satoru Takahashi. "This study was designed based on the critical need to understand the molecular mechanisms through which muscle atrophy occurs in conditions of microgravity and artificial gravity."

Two groups of mice (six per group) were housed aboard the International Space Station for 35 days. One group was subjected to artificial gravity (1 g) and the other to microgravity. All mice were alive upon return to Earth and the team compared the effects of the different onboard environments on skeletal muscles.

"To understand what was happening inside the muscles and cells at the molecular level, we examined the muscle fibers. Our results show that artificial gravity prevents the changes observed in mice subjected to microgravity, including atrophy and changes in gene expression," explained Prof. Takahashi. Transcriptional analysis of revealed that artificial gravity prevented altered expression of atrophy related genes and identified novel candidate genes associated with atrophy. Specifically, a gene called Cacng1 was identified as possibly having a functional role in myotube atrophy.

This work supports the use of spaceflight datasets using 1 g for examining the effects of spaceflight in muscles. These studies will likely aid our understanding of the mechanisms of and may ultimately influence the treatment of related diseases.


Explore further

Space-like gravity weakens biochemical signals in muscle formation

More information: Risa Okada et al. Transcriptome analysis of gravitational effects on mouse skeletal muscles under microgravity and artificial 1 g onboard environment, Scientific Reports (2021). DOI: 10.1038/s41598-021-88392-4
Journal information: Scientific Reports

Citation: Understanding astronaut muscle wasting at the molecular level (2021, May 11) retrieved 14 June 2021 from https://phys.org/news/2021-05-astronaut-muscle-molecular.html
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
183 shares

Feedback to editors

User comments