Understanding the utility of plasmas for medical applications

Understanding the utility of plasmas for medical applications
Evolution of the forward (a) and the reflected (b) ionization waves approaching and reflecting from the conductive dielectric surface. The ionization wave front is represented in the simulations by electron impact ionization source Se (cm-3s-1). The arrows indicate the direction of the IW propagation. Density of O-radicals (c), ozone O3 (d) and singlet delta O2(1Δ) (d) after the passage of forward, reflected, and secondary forward IWs. Credit: Natalia Yu. Babaeva

Plasma medicine is an emerging field, as plasmas show promise for use in a wide range of therapies from wound healing to cancer treatment. Plasma jets are the main plasma sources typically used in plasma-surface applications. Before applications can progress, however, a better understanding of how plasma jets modify the surfaces of biological tissue is required.

To help with this understanding, researchers from the Russian Academy of Sciences conducted computer simulations of the interaction between an atmospheric pressure plasma jet with a surface that has properties similar to blood serum. They present their analysis in the Journal of Applied Physics.

"While using the plasma jets for the purpose of plasma medicine, it is important to know that the presence or absence of the treated surface in vicinity of a jet significantly influences jet parameters," said Natalia Babaeva, one of the authors. "For example, the wounds with blood serum can have different properties. These properties can also vary during the plasma treatment."

Depending on the characteristics of the tissue being treated, the plasma jet can behave in a number of different ways. The ionization waves produced by may reflect back and forth, or they can spread over the tissue as surface discharge.

For the type of plasma Babaeva and her team studied, they found that the biomaterial-like surface can lead to multiple reflections of the plasma jet, and with each passage, the number of electrons and radicals—a type of very —increases. Specifically, the radicals identified are oxygen, hydroxide, , ozone, and , also known as and reactive nitrogen species.

"Reactive oxygen species and reactive nitrogen species are important for the actions of antimicrobial drugs, cancer, and wound healing therapies," Babaeva said, adding that they both play an active role in the immune systems of animals and plants.

Quantifying these radicals and understanding the direction and magnitude of their flow is important for optimizing plasmas for use in , where the ability to control their behavior to some degree is crucial. The team's simulations provide the means to predict this behavior.

"This prediction is very important, as it determines the plasma treatment potential," Babaeva said. "Our research adds some knowledge on the particular behavior of the jet in the presence of highly conductive surfaces."


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More information: Reactive fluxes delivered by plasma jets to conductive dielectric surfaces during multiple reflections of ionization waves, Journal of Applied Physics (2020). aip.scitation.org/doi/10.1063/5.0019350
Journal information: Journal of Applied Physics

Citation: Understanding the utility of plasmas for medical applications (2020, November 24) retrieved 15 January 2021 from https://phys.org/news/2020-11-plasmas-medical-applications.html
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