Promising new method for producing tiny liquid capsules

Promising new method for producing tiny liquid capsules
Microfluidic technology is used to miniaturize a fish oil capsule from its normal size to the size of a printed dot in a book. Credit: Nam-Trung Nguyen

Microcapsules for the storage and delivery of substances are tiny versions of the type of capsule used for fish oil or other liquid supplements, such as vitamin D. A new method for synthesizing microcapsules, reported in AIP Advances, creates microcapsules with a liquid core that are ideal for the storage and delivery of oil-based materials in skin care products. They also show promise in some applications as tiny bioreactors.

Current production methods for microcapsules involve the use of emulsions, but these often require surfactants to ensure stability of the interface between the inner and the one used to create the . Since surfactants can adversely affect the liquids involved, other approaches have been tried, including spraying liquids in a strong electric field.

One technique for creating microcapsules that works reasonably well involves the use of tiny channels. This microfluidics approach requires the complete wetting of the tiny channels with the liquids used to make the droplets. This, again, requires surfactants, complicating the fabrication process.

In this new method, a surfactant-free microfluidics process is used. The technique can produce up to 100 microcapsules per second. The output could be even larger at higher flow rates, according to the authors.

To produce the microcapsules, the investigators created a device by etching tiny channels into hard plastic. Two different liquids, an oily one for the core and a different one for the shell, were injected into the channels.

As the liquids are pumped through, droplets form when the immiscible liquids come into contact. The droplets are kept separate from one another with a third liquid and, finally, irradiated with ultraviolet light. This final step causes the outer shell to polymerize and solidify, trapping the .

The investigators analyzed and optimized the system by trying different flow rates and other operating conditions. The final were examined and allowed to dry overnight at a high temperature, but no evaporation or shrinkage was observed, showing that the microcapsules can be safely stored without rupturing. This makes them ideal for pharmaceutical or skin care applications.

"Another application for microcapsules would be the , PCR," said co-author Nam-Trung Nguyen, of Griffith University in Australia.

Keeping the PCR samples in these tiny capsules allows for implementation of a technique known as digital PCR.

"Each could serve as a single microreactor, eliminating the need for well plates," said Nguyen.

More information: "Surfactant-free, UV-curable core-shell microcapsules in a hydrophilic PDMS microfluidic device," AIP Advances (2020).

Journal information: AIP Advances

Citation: Promising new method for producing tiny liquid capsules (2020, June 2) retrieved 7 December 2023 from
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