Ingestible medical devices can be broken down with light

Ingestible medical devices can be broken down with light
Light-degradable hydrogels as dynamic triggers in GI devices. (A) Schematic of balloon insertion and inflation (left), degradation via either an endoscopic or untethered LED light source (middle), and subsequent deflation (right). (B) Casting of oNB-PAAM gel pins (top) and assembled balloon sealed with a cast gel pin (bottom). Photo credit: Ritu Raman, MIT. (C) Balloon is inserted through the esophagus and swells in the stomach as observed endoscopically 1 min after insertion (top) and radiographically (bottom) immediately after insertion and after 6 hours in vivo. (D) Design of LED cap that can be attached to the inserted end of an endoscope. Wires to power the LEDs are threaded through the endoscope, and a hole in the array maintains visibility through the endoscope’s integrated camera. A magnet at the center of the array enables docking to the metallic piece attached to the sealed end of the balloon. (E) Design of ingestible pill-shaped LED. Computer-aided design (CAD) rendering shows assembly process for ingestible LED: Batteries, LED, and magnet are inserted into 3D-printed hollow cylindrical body and sealed with epoxy into a water-tight device. LED is turned on when a metal conductive tab is pushed into the slit in the side of the device. Magnetic docking of the LED to the balloon in vivo is observed radiographically (bottom right). (F) After the light-triggerable oNB-PAAM gel pin is degraded, the filler leaks out and the balloon decreases significantly in size as observed radiographically at t = 0 hours (top) and 6 hours (bottom). (G) The balloons degraded using both the endoscopic LED array and untethered LED decreased significantly in size at t = 6 hours as compared to a control (n = 3, P < 0.05), indicating successful on-demand activation of the oNB-PAAM gel trigger. (H) Schematic of esophageal stent device composed of an oNB-PAMPS gel ring with PCL beads. (I) Photograph (top) and radiographic image (bottom) of the assembled device. PCL beads are painted with a barium sulfate paint to increase visibility via x-ray. Photo credit: Ritu Raman, MIT. (J) The assembled device is placed inside an ex vivo esophagus, and swelling of the device ensures a press fit with the tissue that withstands compression. (K) Reduction in the esophageal stents’ resistive force to external compression in vitro and ex vivo after light-triggered degradation (n = 3, P < 0.05). (L) Top: Following degradation with the endoscopic LED array described in (D), the gel changes color from clear to orange, an indicator of degradation as observed in fig. S6. Bottom: The degraded gel leaks out of the esophagus when the tissue is compressed to half its original width commensurate with esophageal peristaltic movement in vivo. Photo credit: Ritu Raman, MIT. Science Advances (2020).

A variety of medical devices can be inserted into the gastrointestinal tract to treat, diagnose, or monitor GI disorders. Many of these have to be removed by endoscopic surgery once their job is done. However, MIT engineers have now come up with a way to trigger such devices to break down inside the body when they are exposed to light from an ingestible LED.

The new approach is based on a -sensitive hydrogel that the researchers designed. Incorporating this material into could avoid many endoscopic procedures and would give doctors a faster and easier way to remove devices when they are no longer needed or are not functioning properly, the researchers say.

"We are developing a set of systems that can reside in the gastrointestinal tract, and as part of that, we're looking to develop different ways in which we can trigger the disassembly of devices in the GI tract without the requirement for a major procedure," says Giovanni Traverso, an assistant professor of mechanical engineering, a gastroenterologist at Brigham and Women's Hospital, and the senior author of the study.

In a study in pigs, the researchers showed that devices made with this light-sensitive hydrogel can be triggered to break down after being exposed to blue or from a small LED.

Ritu Raman, a postdoc at MIT's Koch Institute for Integrative Cancer Research, is the lead author of the paper, which appears today in Science Advances. Other authors of the paper are former technical associates Tiffany Hua, Jianlin Zhou, Tina Esfandiary, and Vance Soares; technical associates Declan Gwynne, Joy Collins, and Siddartha Tamang; graduate student Simo Pajovic; Division of Comparative Medicine veterinarian Alison Hayward; and David H. Koch Institute Professor Robert Langer.

Controlled breakdown

Over the past several years, Traverso and Langer have developed many ingestible devices designed to remain in the GI tract for extended periods of time. They have also worked on a variety of strategies to control the breakdown of such devices, including methods based on changes in pH or temperature, or exposure to certain chemicals.

"Given our interests in developing systems that can reside for prolonged periods in the gastrointestinal tract, we continue to investigate a range of approaches to facilitate the removal of these systems in the setting of adverse reaction or when they are no longer needed," Traverso says. "We're really looking at different triggers and how they perform, and whether we can apply them to different settings."

In this study, the researchers explored a light-based trigger, which they believed could offer some advantages over their earlier approaches. One potential advantage is that light can act at a distance and doesn't need to come into direct contact with the material being broken down. Also, light normally does not penetrate the GI tract, so there is no chance of accidental triggering.

To create the new material, Raman designed a light-sensitive hydrogel based on a material developed in the lab of Kristi Anseth, a former Langer lab postdoc who is now a professor of chemical and biological engineering at the University of Colorado at Boulder. This polymer gel includes a chemical bond that is broken when exposed to a wavelength of light between 405 and 365 nanometers (blue to ultraviolet).

Raman decided that instead of making a material composed exclusively of that light-sensitive polymer, she would use it to link together stronger components such as polyacrylamide. This makes the overall material more durable but still allows it to break apart or weaken when exposed to the right wavelength of light. She also constructed the material as a "double network," in which one polymer network surrounds another.

"You're forming one polymer network and then forming another polymer network around it, so it's really entangled. That makes it very tough and stretchy," Raman says.

The material's properties can be tuned by varying the composition of the gel. When the light-sensitive linker makes up a higher percentage of the material, it breaks down faster in response to light but is also mechanically weaker. The researchers can also control how long it takes to break down the material by using different wavelengths of light. Blue light works more slowly but poses less risk to cells that are sensitive to damage from ultraviolet light.

Deflated by light

The gel and its breakdown products are biocompatible, and the gel can be easily molded into a variety of shapes. In this study, the researchers used it to demonstrate two possible applications: a seal for a bariatric balloon and an esophageal stent. Standard bariatric balloons, which are sometimes used to help treat obesity, are inflated in a patient's stomach and filled with saline. After about six months, the balloon is removed by endoscopic surgery.

In contrast, the bariatric balloon that the MIT team designed can be deflated by exposing the seal to a tiny LED light, which would in principle be swallowed and then pass out of the body. Their balloon is made of latex and filled with sodium polyacrylate, which absorbs water. In this study, the researchers tested the balloons in pigs and found that the balloons swelled up as soon as they were placed in the stomach. When a small, ingestible LED emitting was placed in the stomach for about six hours, the balloons slowly deflated. With a higher-power light, the material broke down within 30 minutes.

The researchers also molded the light-sensitive gel into an esophageal stent. Such stents are sometimes used to help treat esophageal cancer or other disorders that cause a narrowing of the esophagus. A light-triggerable version could be broken down and passed through the digestive tract when no longer needed.

In addition to those two applications, this approach could be used to create other kinds of degradable devices, such as vehicles for delivering drugs to the , according to the researchers.

"This study is a proof of concept that we can create this kind of material, and now we're thinking about what are the best applications for it," Traverso says.

More information: "Light-degradable hydrogels as dynamic triggers for gastrointestinal applications" Science Advances (2020). DOI: 10.1126/sciadv.aay0065 ,

Journal information: Science Advances

Citation: Ingestible medical devices can be broken down with light (2020, January 17) retrieved 21 February 2024 from
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