3-D body mapping could identify, treat organs, cells damaged from medical conditions

3-D body mapping could identify, treat organs, cells damaged from medical conditions
Credit: ACS

Medical advancements can come at a physical cost. Often following diagnosis and treatment for cancer and other diseases, patients' organs and cells can remain healed but damaged from the medical condition.

In fact, one of the fastest growing medical markets is healing and/or replacing organs and cells already treated, yet remain damaged by cancer, and other medical issues. The global engineering market is expected to reach $11.5 billion by 2022. That market involves researchers and medical scientists working to repair tissues damaged by some of the world's most debilitating cancers and diseases.

One big challenge remains for the market—how to monitor and continuously test the performance of engineered tissues and cells to replace damaged ones. Purdue University researchers have come up with a 3-D mapping technology to monitor and track the behavior of the engineered cells and tissues and improve the success rate for patients who have already faced a debilitating . The technology is published in the June 19 edition of ACS Nano.

"My hope is to help millions of people in need," said Chi Hwan Lee, an assistant professor of biomedical engineering and in Purdue's College of Engineering, who leads the research team. "Tissue engineering already provides new hope for hard-to-treat disorders, and our technology brings even more possibilities."

The Purdue team created a tissue scaffold with sensor arrays in a stackable design that can monitor electrophysiological activities of and tissues. The technology uses the information to produce 3-D maps to track activity.

"This device offers an expanded set of potential options to monitor cell and tissue function after surgical transplants in diseased or damaged bodies," Lee said. "Our technology offers diverse options for sensing and works in moist internal body environments that are typically unfavorable for electronic instruments."

Lee said the Purdue device is an ultra-buoyant scaffold that allows the entire structure to remain afloat on the cell culture medium, providing complete isolation of the entire electronic instrument from the wet conditions inside the body.

Lee and his team have been working with Sherry Harbin, a professor in Purdue's Weldon School of Biomedical Engineering, to test the device in stem cell therapies with potential applications in the regenerative treatment of diseases.


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More information: Hyungjun Kim et al, Sensor-Instrumented Scaffold Integrated with Microporous Spongelike Ultrabuoy for Long-Term 3D Mapping of Cellular Behaviors and Functions, ACS Nano (2019). DOI: 10.1021/acsnano.9b02291
Journal information: ACS Nano

Provided by Purdue University
Citation: 3-D body mapping could identify, treat organs, cells damaged from medical conditions (2019, June 27) retrieved 21 July 2019 from https://phys.org/news/2019-06-d-body-cells-medical-conditions.html
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