Antibiotic resistance in the environment linked to fecal pollution

Credit: CC0 Public Domain

Increased levels of antibiotic resistant bacteria in the environment may have different causes. It could be a consequence of on-site selection from antibiotic residues in the environment, hence promoting the evolution of new forms of resistance. Alternatively, it is simply due contamination by fecal bacteria that often tend to be more resistant than other bacteria. Understanding which explanation is correct is fundamental to manage risks.

A study published in Nature Communications shows that crAssphage, a virus specific to bacteria in human feces, is highly correlated to the abundance of antibiotic resistance genes in . This indicates that fecal pollution can largely explain the increase in resistant bacteria often found in human-impacted environments. There was, however, one clear exception where resistance genes were very common also without the presence of the phage—environments polluted with high levels of from manufacturing.

Joakim Larsson, Professor in Environmental Pharmacology at Sahlgrenska Academy, University of Gothenburg, and one of the co-authors, says, "These finding are important as they can inform management of human health risks associated with antibiotic resistant in the . While antibiotic residues is clearly the cause for the exceptionally high levels of resistance found near some manufacturing sites, fecal pollution is probably the explanation in most other places."

Does this mean that we do not need to care about the low levels of antibiotics released from sewage treatment plants world-wide? "The study indicates the importance of taking into account the level of fecal pollution when interpreting findings of antibiotic resistance in the environment. It implicates that one often do not need to explain such findings by on-site selection from residual antibiotics. But it does not exclude that there still is selection by low levels of antibiotics in the environment going in in parallel. Other findings still suggest that low, environmental levels of certain antibiotics could select for resistance. This needs further research," says Larsson.

More information: Antti Karkman et al. Fecal pollution can explain antibiotic resistance gene abundances in anthropogenically impacted environments, Nature Communications (2019). DOI: 10.1038/s41467-018-07992-3

Journal information: Nature Communications

Citation: Antibiotic resistance in the environment linked to fecal pollution (2019, January 8) retrieved 17 July 2024 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Explore further

Study discovers over 6,000 antibiotic resistance genes in the bacteria that inhabit the human gut


Feedback to editors