Researchers identify enzyme responsible for helping cancer tumors spread

Researchers identify enzyme responsible for helping cancer tumors spread
Steven Van Doren unraveled how a cancer-critical enzyme is positioned on cell surfaces. Credit: University of Missouri-Columbia

Researchers at the University of Missouri have unraveled how a cancer-critical enzyme is positioned on cell surfaces. The enzyme enables tumor cells to tunnel through collagen, creating a convenient path for tumors to spread cancer throughout the body. This breakthrough is an important step toward the development of pharmaceuticals that can prevent and treat the spreading of cancers in the body.

In order to spread cancer, tumor must make their way through , which is the most abundant protein in the human body and provides structural strength to bones and tissue. One enzyme, which scientists have dubbed MT1-MMP, can "sit" on the surface of a tumor cell and digest the collagen in its path, opening a tunnel for tumor cells to spread. The new results suggest that it may be possible to disrupt how this enzyme "sits" on a tumor cell, potentially blocking its ability to digest collagen and hindering the spread of cancer.

"The MT1-MMP enzyme has four 'blades,' like the blades on a propeller. Our study shows that two of the blades stick to tumor cells," said Steven Van Doren, a professor of biochemistry in MU's College of Agriculture, Food and Natural Resources. "Because there are two blades, the enzyme can stick to the cell in two different ways. We found that one orientation allows the enzyme to digest the collagen while the other probably interferes with that process."

Van Doren and his colleagues used an 800 MHz (NMR) spectrometer, the most powerful NMR spectrometer in the state of Missouri, to observe how the MT1-MMP enzyme bound itself to . The spectrometer used to track the relevant molecules, allowing the researchers to identify the specific "blades" that are critical for binding to cells and digesting collagen. The conclusions were corroborated by other measurements using fluorescent light. By shedding light on the specific positioning of these blades and the corresponding interactions with collagen, researchers have opened the door to interfering in this enzyme's digestion of collagen, a strategy that could close an important avenue for the spread of cancer through the body.

Credit: University of Missouri-Columbia

"We now understand the importance of targeting enzymes like this one selectively," Van Doren said. "This class of enzyme—metalloproteinases—had been studied decades ago, but the focus was too broad. As a result, the studies failed and these enzymes were neglected. Focusing specifically on the MT1-MMP enzyme allowed us to gather specific results that have practical applications for potential pharmaceuticals and further research."

Van Doren said the next stage of research will be to identify compounds that can influence the positioning of the enzyme and block collagen digestion. Now that the is better understood, there are numerous potential applications not only for cancer research, but also for the treatment of arthritis to decrease and to decrease lung damage from the flu, according to Van Doren.

The study, "MT1-MMP binds membranes by opposite tips of its β propeller to position it for pericellular proteolysis," was published in Structure.

Explore further

New studies create better understanding of cancer-spreading enzymes

More information: Tara C. Marcink et al. MT1-MMP Binds Membranes by Opposite Tips of Its β Propeller to Position It for Pericellular Proteolysis, Structure (2018). DOI: 10.1016/j.str.2018.10.008
Journal information: Structure

Citation: Researchers identify enzyme responsible for helping cancer tumors spread (2018, December 6) retrieved 17 August 2019 from
This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.

Feedback to editors

User comments

Dec 06, 2018
DISCLAIMER: artists against 419 ("aa419") identifies fraudulent websites and makes this data available as a public service. We discourage any form of communication with these websites. If you chose to communicate with them you do so at your own risk.

The publicly available whois information listed in the aa419 database was accurate on the date that the website information was entered into the aa419 database. Inclusion in our database does not necessarily indicate criminal activity on the part of the registrant, host or any affiliated companies or individuals.

All data is provided for your personal information only. aa419 and its members shall not be liable for any errors in the database or for any actions taken in reliance thereon.
Back to List

Id 132809
Site Name Natural Herbal Gardens
Scam Type non-delivery

Please sign in to add a comment. Registration is free, and takes less than a minute. Read more